Multivariate model detailing the components of the MACS rule (rounded values are presented)
| Variable | Constant | OR (95% CI) | p Value |
|---|---|---|---|
| a. High sensitivity troponin T* | 0.068 | 1.1 (1.0 to 1.1) | <0.0001 |
| b. Heart-type fatty acid binding protein* | 0.17 | 1.2 (1.0 to 1.4) | 0.018 |
| c. ECG ischaemia | 1.75 | 5.8 (3.1 to 10.8) | <0.0001 |
| d. Sweating observed | 1.85 | 6.3 (3.0 to 13.3) | <0.0001 |
| e. Vomiting | 1.72 | 5.6 (1.9 to 16.6) | 0.002 |
| f. Systolic blood pressure <100 mm Hg | 1.46 | 4.3 (1.2 to 15.1) | 0.022 |
| g. Worsening angina | 0.92 | 2.5 (1.2 to 5.2) | 0.014 |
| h. Pain radiating to right arm or shoulder | 0.87 | 2.4 (1.0 to 5.6) | 0.044 |
| Constant | −4.83 | – | – |
The model estimates the probability (p) of MACE as follows (rounded values are presented): p=1/(1+e−(0.068a + 0.17b + 1.75c + 1.85d + 1.72e + 1.46f + 0.92g + 0.87h − 4.83)). For each categorical variable, a value of 1 is assigned if the characteristic is present and 0 if absent.
*ORs are presented for a 1 unit increase (ng/L for hs-cTnT; ng/mL for H-FABP).
MACE, major adverse cardiac events; MACS, Manchester Acute Coronary Syndromes.