Use of oral glucocorticoids and cardiovascular or cerebrovascular events stratified by disease indication: rheumatoid arthritis (RA, n = 1515), chronic obstructive pulmonary disease (COPD, n = 16440), other (n = 31240)
| Adjusted OR (95% CI) | |||
|---|---|---|---|
| RA cohort* | COPD cohort† | Other cohort† | |
| *Adjusted for use antidiabetic drugs, cardiovascular drugs, NSAIDs, DMARDs, and history or treatment of lung diseases; †adjusted for use of antidiabetic drugs, cardiovascular drugs, NSAIDs, number of general practitioner visits, BMI, and smoking. | |||
| All outcomes | |||
| Timing of oral glucocorticoid use | |||
| Current use | 1.37 (1.16 to 1.62) | 1.68 (1.57 to 1.80) | 1.13 (0.99 to 1.29) |
| Recent use | 1.28 (0.98 to 1.68) | 1.06 (0.98 to 1.15) | 1.12 (0.92 to 1.35) |
| Past use | 1.17 (0.87 to 1.58) | 1.08 (1.00 to 1.16) | 1.13 (0.95 to 1.33) |
| Ischaemic heart disease events | |||
| Timing of oral glucocorticoid use | |||
| Current use | 1.36 (1.02 to 1.81) | 1.28 (1.06 to 1.55) | 1.09 (0.96 to 1.22) |
| Recent use | 1.09 (0.67 to 1.77) | 0.94 (0.77 to 1.14) | 0.97 (0.81 to 1.17) |
| Past use | 1.34 (0.82 to 2.19) | 1.05 (0.87 to 1.26) | 1.12 (0.95 to 1.32) |
| Heart failure | |||
| Timing of oral glucocorticoid use | |||
| Current use | 1.55 (1.16 to 2.07) | 3.03 (2.69 to 3.40) | 1.89 (1.65 to 2.16) |
| Recent use | 1.52 (0.98 to 2.33) | 1.39 (1.22 to 1.58) | 1.38 (1.10 to 1.74) |
| Past use | 1.12 (0.69 to 1.84) | 1.14 (1.00 to 1.30) | 1.42 (1.14 to 1.77) |
| Stroke/transient ischaemic attack | |||
| Timing of oral glucocorticoid use | |||
| Current use | 1.23 (0.92 to 1.64) | 0.81 (0.71 to 0.93) | 1.03 (0.92 to 1.16) |
| Recent use | 1.23 (0.73 to 2.08) | 0.88 (0.76 to 1.02) | 0.93 (0.77 to 1.13) |
| Past use | 1.07 (0.60 to 1.91) | 1.00 (0.87 to 1.16) | 1.29 (1.09 to 1.53) |