RT Journal Article
SR Electronic
T1 Impact of frequent premature ventricular contractions on pregnancy outcomes
JF Heart
JO Heart
FD BMJ Publishing Group Ltd and British Cardiovascular Society
SP 1370
OP 1375
DO 10.1136/heartjnl-2017-312624
VO 104
IS 16
A1 Tong, Calvin
A1 Kiess, Marla
A1 Deyell, Marc William
A1 Qiu, Michael
A1 Orgad, Merav
A1 Rychel, Valerie
A1 Claman, Ariel
A1 Hardwick, Emma
A1 McCarthy, Beverly
A1 Silversides, Candice K
A1 Grewal, Jasmine
YR 2018
UL http://heart.bmj.com/content/104/16/1370.abstract
AB Objectives To determine cardiac and fetal/neonatal event rates among pregnant women with premature ventricular contractions (PVCs) and compare with control groups.Methods Prospective case–control cohort study: 53 consecutive pregnancies in 49 women referred to the St. Paul’s Hospital between 2010 and 2016 with PVC burden >1% in women without underlying cardiac disease. Maternal cardiac and fetal/neonatal outcomes were compared with two pregnant control groups: (1) supraventricular tachycardia (SVT) group of 53 women referred for a history of SVT/SVT in the current pregnancy and (2) low-risk group of 53 women with no cardiac disease.Results The maximal PVC burden was 9.2% (range 1.1%–58.7%). Six of 53 (11%) pregnancies were complicated by a maternal cardiac event: heart failure n=1 and sustained ventricular tachycardia requiring therapy n=5 as compared with no cardiac events in both control groups. All women with an adverse event had a PVC burden >5%. Seven (13%) pregnancies were complicated by an adverse fetal and/or neonatal event and this was similar to the normal control group (5 (9%), P=0.45) and significantly less than the SVT group (16 (30%), P=0.03). The adverse fetal event was driven by small for gestational age neonates and preterm delivery.Conclusions In our cohort of pregnant women with a structurally normal heart and ‘high’ PVC burden, we found an adverse maternal event rate of 11%, and all events were successfully managed with medical therapy. The rate of adverse fetal events in the PVC group was similar to the normal control group.