Effect of TXA on new and progressive haemorrhage
| TXA group | Placebo group | RR (95% CI) unadjusted | P value (two-tailed) | RR (95% CI) adjusted* | P value (two-tailed) | |
| New haemorrhage | ||||||
| ≤3 hours since injury | 108/261 (41%) | 129/284 (45%) | 0.91 (0.75 to 1.10) | 0.34 | 0.89 (0.73 to 1.08) | 0.22 |
| >3 hours since injury | 36/138 (26%) | 45/129 (35%) | 0.75 (0.52 to 1.08) | 0.12 | 0.69 (0.48 to 0.99) | 0.044 |
| All patients | 144/399 (36%) | 174/413 (42%) | 0.86 (0.72 to 1.02) | 0.079 | 0.85 (0.72 to 1.01) | 0.069 |
| Exclude unreactive pupils (one/both) | 108/332 (33%) | 140/346 (40%) | 0.80 (0.66 to 0.98) | 0.033 | 0.80 (0.66 to 0.98) | 0.030 |
| Progressive haemorrhage | ||||||
| ≤3 hours since injury | 76/261 (29%) | 88/284 (31%) | 0.94 (0.73 to 1.22) | 0.64 | 0.92 (0.72 to 1.19) | 0.53 |
| >3 hours since injury | 39/138 (28%) | 42/129 (33%) | 0.87 (0.60 to 1.25) | 0.45 | 0.86 (0.58 to 1.28) | 0.46 |
| All patients | 115/399 (29%) | 130/413 (31%) | 0.92 (0.74 to 1.13) | 0.41 | 0.91 (0.74 to 1.13) | 0.41 |
| Exclude unreactive pupils (one/both) | 92/332 (28%) | 111/346 (32%) | 0.86 (0.69 to 1.09) | 0.22 | 0.87 (0.69 to 1.10) | 0.24 |
*Adjusted for time from injury to pre-randomisation scan, age, GlasgowComa Score, pupil reaction, systolic blood pressure and participating hospital.
RR, relative risk; TXA, tranexamic acid.