The trend of uterus transplantation publications increased exponentially after 2010. Fertility and Sterility, Lancet, American Journal of Transplantation, and Human Reproduction were the highly cited journals. Furthermore, the results found that more than one-third of the highly cited papers were review papers (39%) and 27% were clinical trial studies.

Our study introduces a bicornuate uterus transplantation model in Lewis rats, comparable in safety and feasibility to the unicornuate model, enabling longitudinal graft health monitoring for UTx research.

The first animal model of hypothermic machine perfusion in uterus transplantation showed that this new technique was not only feasible, but it also seemed to provide a better preparation for ischaemia-reperfusion phenomena despite a significantly longer warm ischaemia time.

A factor that impacts graft survival in organ transplantation is the warm ischemia time. In uterine transplantation specifically, at least two vascular anastomoses are performed on each side of the uterus, and the graft revascularization takes place when the vascular clamps of the arteries and veins are released on both sides simultaneously. For this reason, the warm ischemia time in uterine transplant is expected to be considerably long. The purpose of this study was to compare the sequential technique of uterine graft revascularization, which aims to reduce the warm ischemia time of the procedure, with the simultaneous revascularization technique.

This study establishes an interspecies sodium deoxycholate (SDC)-based decellularization C) protocol that generates bioactive, non-toxic uterus scaffolds. Furthermore, preconditioning with metalloproteinases (MMP) does not affect the scaffold's properties, improving recellularization potential and attenuating their immunogenicity. Graphical abstract created with BioRender.com

Despite the demonstrated feasibility of uterus transplantation as a treatment for absolute uterine infertility little is known about the acceptance of it among the target population. This study indicates that uterus transplantation is accepted by most women who would benefit from the procedure and their relatives, and also by those women who do not need it.

Unequal access and restricted access to uterine transplants are experienced as an injustice by some women with MRKH syndrome despite their high demand. Numerous limitations such as selection criteria, autonomy, and innovation in healthcare are at the forefront.

38% of women with MRKH syndrome are inadequately explored for associated malformations. Early assessment of ovarian reserve is necessary at diagnosis in women with MRKH syndrome. MRKH syndrome may have a familial and hereditary dimension.

Psychological evaluation of potential candidates for the uterus transplantation French Trial shows that providing psychological support is essential throughout all the process until explanation.

This study is the first in Australia to assess the psychosocial functioning of potential uterus transplant recipients. Findings show that participants reported strong emotional well-being, supported by high levels of social support and a transformative desire for motherhood, highlighting the importance of tailored psychological assessments in future research.

Uterus transplantation is moving out of clinical trials into clinical practice. Uterus transplantation candidates have unique mental health challenges. New guidelines should aim to liberalize inclusion criterion to all patients with mental health comorbidity for evaluation.

Living Donor Uterus Transplant Research Project in Singapore: Progress of the First Case.

Pregnancies and live births after uterus transplantation are at high-risk of maternal complications such as hypertensive disorders and premature rupture of membranes, as well as perinatal complications including preterm birth and respiratory distress syndrome.