RT Journal Article SR Electronic T1 A review of the stroke volume response to upright exercise in healthy subjects JF British Journal of Sports Medicine JO Br J Sports Med FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine SP 190 OP 195 DO 10.1136/bjsm.2004.013037 VO 39 IS 4 A1 Vella, C A A1 Robergs, R A YR 2005 UL http://bjsm.bmj.com/content/39/4/190.abstract AB Traditionally, it has been accepted that, during incremental exercise, stroke volume plateaus at 40% of Vo2max. However, recent research has documented that stroke volume progressively increases to Vo2max in both trained and untrained subjects. The stroke volume response to incremental exercise to Vo2max may be influenced by training status, age, and sex. For endurance trained subjects, the proposed mechanisms for the progressive increase in stroke volume to Vo2max are enhanced diastolic filling, enhanced contractility, larger blood volume, and decreased cardiac afterload. For untrained subjects, it has been proposed that continued increases in stroke volume may result from a naturally occurring high blood volume. However, additional research is needed to evaluate the importance of blood volume, or other mechanisms, that influence the stroke volume response to exercise in untrained subjects.