Chondrocytes

SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
Augustin Latourte, Sarah Jaulerry, Alice Combier, Chahrazad Cherifi, Yohan Jouan, Thierry Grange, Julien Daligault, Hang-Korng Ea, Martine Cohen-Solal, Eric Hay, Pascal Richette

Annals of the Rheumatic Diseases Dec 2024, 83 (12) 1781-1790; DOI: 10.1136/ard-2024-225645
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
Norbert Bittner, Chenfu Shi, Danyun Zhao, James Ding, Lorraine Southam, Diane Swift, Peter Kreitmaier, Mauro Tutino, Odysseas Stergiou, Jackson T S Cheung, Georgia Katsoula, Jenny Hankinson, Jeremy Mark Wilkinson, Gisela Orozco, Eleftheria Zeggini

Annals of the Rheumatic Diseases Aug 2024, 83 (8) 1048-1059; DOI: 10.1136/ard-2023-224945
Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration
Yue Fan, Xuzhao Bian, Xiaogao Meng, Lei Li, Laiyi Fu, Yanan Zhang, Long Wang, Yan Zhang, Dalong Gao, Xiong Guo, Mikko Juhani Lammi, Guangdun Peng, Shiquan Sun

Annals of the Rheumatic Diseases Jul 2024, 83 (7) 926-944; DOI: 10.1136/ard-2023-224420
Prognostic model to predict the incidence of radiographic knee osteoarthritis
Rocío Paz-González, Vanesa Balboa-Barreiro, Lucia Lourido, Valentina Calamia, Patricia Fernandez-Puente, Natividad Oreiro, Cristina Ruiz-Romero, Francisco J Blanco

Annals of the Rheumatic Diseases May 2024, 83 (5) 661-668; DOI: 10.1136/ard-2023-225090
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
Chaochang Li, Mireia Alemany-Ribes, Rosanne M Raftery, Uzochi Nwoko, Matthew L Warman, April M Craft

Annals of the Rheumatic Diseases Dec 2023, 82 (12) 1547-1557; DOI: 10.1136/ard-2023-224304
Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice
John A Collins, C James Kim, Ashley Coleman, Abreah Little, Matheus M Perez, Emily J Clarke, Brian Diekman, Mandy J Peffers, Susanna Chubinskaya, Ryan E Tomlinson, Theresa A Freeman, Richard F Loeser

Annals of the Rheumatic Diseases Nov 2023, 82 (11) 1464-1473; DOI: 10.1136/ard-2023-224385
Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis
Manabu Kawata, Takeshi Teramura, Philip Ordoukhanian, Steven R Head, Padmaja Natarajan, Aishwarya Sundaresan, Merissa Olmer, Hiroshi Asahara, Martin K Lotz

Annals of the Rheumatic Diseases Aug 2022, 81 (8) 1179-1188; DOI: 10.1136/annrheumdis-2021-221867
Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis
Kai-di Wang, Xiang Ding, Nan Jiang, Chao Zeng, Jing Wu, Xian-yi Cai, Aubryanna Hettinghouse, Asya Khleborodova, Zi-Ning Lei, Zhe-Sheng Chen, Guang-hua Lei, Chuan-ju Liu

Annals of the Rheumatic Diseases Apr 2022, 81 (4) 544-555; DOI: 10.1136/annrheumdis-2021-221380
Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours
Alice Courties, Merissa Olmer, Kevin Myers, Phillip Ordoukhanian, Steven R Head, Padmaja Natarajan, Francis Berenbaum, Jérémie Sellam, Martin K Lotz

Annals of the Rheumatic Diseases May 2023, 82 (5) 710-718; DOI: 10.1136/ard-2022-223470
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
Haiyan Zhang, Yan Shao, Zihao Yao, Liangliang Liu, Hongbo Zhang, Jianbin Yin, Haoyu Xie, Kai Li, Pinglin Lai, Hua Zeng, Guozhi Xiao, Chun Zeng, Daozhang Cai, Xiaochun Bai

Annals of the Rheumatic Diseases May 2022, 81 (5) 676-686; DOI: 10.1136/annrheumdis-2021-221513

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