Multivariate Cox regression analysis for damage accrual in the validation cohort
| Factors | Model 1 | Model 2 | ||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender (female) | 0.606 (0.277 to 1.326) | 0.2099 | 0.500 (0.236 to 1.059) | 0.0704 |
| Disease duration (years) | 1.036 (0.999 to 1.073) | 0.0554 | 1.041 (1.004 to 1.079) | 0.0297 |
| Age at diagnosis (≤25 years) | 0.690 (0.356 to 1.339) | 0.2724 | 0.6307 (0.319 to 1.249) | 0.1860 |
| Lupus nephritis at baseline (yes) | 0.653 (0.318 to 1.340) | 0.2452 | 0.874 (0.438 to 1.742) | 0.7017 |
| Prednisolone at baseline (mg/day) | 1.047 (0.990 to 1.106) | 0.1097 | 1.078 (1.021 to 1.138) | 0.0066 |
| Immunosuppressants at baseline (yes) | 1.057 (0.530 to 2.112) | 0.8748 | 1.084 (0.5502 to 2.135) | 0.8160 |
| amSLE-DAS (score) | 1.234 (1.134 to 1.320) | <0.0005 | ||
| amSLEDAI (score) | 1.243 (1.131 to 1.365) | <0.0005 | ||
Model 1: model with amSLE-DAS as time-dependent covariate. Model 2: model with amSLEDAI as time-dependent covariate.
amSLEDAI, adjusted mean of SLEDAI-2K (time-dependent covariate); amSLE-DAS, adjusted mean of SLE-DAS (time-dependent covariate).