Table 4

DAS28 response data by genotype and association p values for three successfully genotyped SNPs in 1334 individuals

										First and additional cohorts combined (n=1334)
												Additive model				Dominant model
SNP	Gene	Chr	bp	Genotype	Count	Mean baseline DAS28	SD baseline DAS28	Mean change in DAS28	SD change in DAS28	HWE exact p value	Genotypic global p value	Global p value	Coef	Min 95	Max 95	Global p value	Coef	Min 95	Max 95
rs10865035	AFF3	2	100202166	AA	320	6.66	1.01	−2.30	1.51	0.228	0.036	0.015	−0.14	−0.25	−0.03	0.013	−0.23	−0.41	−0.05
				AG	688	6.65	0.97	−2.51	1.49
				GG	323	6.66	0.98	−2.59	1.57
rs7574865	STAT4	2	191672878	GG	738	6.69	0.97	−2.56	1.51	0.469	0.173	0.203	0.08	−0.04	0.21	0.091	0.13	−0.02	0.29
				GT	514	6.64	0.98	−2.38	1.56
				TT	80	6.50	1.08	−2.42	1.36
rs763361	CD226	18	65682622	TT	359	6.62	1.01	−2.60	1.44	0.622	0.141	0.048	0.11	0.00	0.22	0.098	0.15	−0.03	0.32
				TC	657	6.65	0.95	−2.48	1.56
				CC	318	6.69	1.03	−2.36	1.51

Significant p values (<0.05) are shown in bold type, italic indicates p<0.10.
bp, base pairs; Chr, chromosome; Coef, coefficient for minor allele (except at rs10865035); DAS, disease activity score; HWE, Hardy–Weinberg equilibrium; SNP, single nucleotide polymorphism.