Participant characteristics
| Participant characteristics | N=1253 |
|---|---|
| Mean age (SD, range), years | 62.3 (7.9, 50–79) |
| Female, n (%) | 763 (60.9) |
| Mean BMI (SD, range), kg/m2 | 30.0 (4.9, 18.0–55.8) |
| Baseline tibiofemoral osteoarthritis (KL ≥2), n (%) | 550 (43.9) |
| Baseline presence of SBA, n (%) | 416 (33.2) |
| Alignment, n (%) | |
| Neutral (179–181°) | 392 (31.3) |
| Varus (<179 °) | 612 (48.8) |
| Valgus (>181°) | 249 (19.9) |
| Whole body BMD, g/cm3 (SD, range) | |
| Women | 1.10 (0.11, 0.80–1.45) |
| Men | 1.24 (0.12, 0.92–1.69) |
BMD, bone mineral density; BMI, body mass index; KL, Kellgren and Lawrence grade; SBA, subchondral bone attrition.