Table 2 Final ratings for outcome domains in studies of chronic gout
Median rating (30th to 70th percentiles)‡Disagreement index§
Adverse effects of intervention*1 (1 to 2)0.22
Serum urate*1 (1 to 1)0
Gout flare recurrence*1 (1 to 1)0
Tophus regression*2 (2 to 2)0
Health-related quality of life*2 (1.6 to 3)0.41
Pain2 (1 to 2.4)0.33
Patient global*2 (1 to 2)0.22
Physician global2 (1 to 3)0.52
Work disability (absentee-ism or presentee-ism)2 (2 to 3)0.32
Joint inflammation2 (2 to 4)0.85
Physical function*†
    Functional disability (difficulty with daily activities)2 (1 to 3)0.52
    Joint impairment (loss of joint motion)3 (2 to 3)0.32
Joint damage imaging*3 (3 to 4)0.32
Participation (life-role)*3 (2 to 4)0.85
Health care utilisation3 (3 to 3)0
Costs3 (3 to 4)0.32
Patient utility (value of current health state)3 (2 to 3)0.32
Comorbidities3 (2 to 4)0.85
Acute phase marker4 (3 to 5)0.52
Total body urate pool5 (3.4 to 6)0.53
Impact on family5 (4 to 6)0.37
Absence of urate crystals from knee synovial fluid5 (4 to 6)0.37
Depression6 (4 to 6)0.37
  • *Domain recommended by OMERACT SIG.

  • †This item was rated highly in the first iteration (median 2) but respondents requested more precise clarification of meaning for subsequent iterations.

  • ‡Ratings of 1–3 indicate item should be included in studies of gout; 4 indicates uncertainty; 5–7 indicate item should not be included in studies of gout.

  • §A disagreement index of less than 1 indicates no disagreement.10