Table 7 Baseline BML and change of BML and their relation to cartilage loss on the BLOKS and WORMS scales in the lateral TF compartment

	Adjusting for age, sex, BMI				Adjusting for age, sex, BMI, alignment
	Baseline BML		Change of BML		Baseline BML		Change of BML
	Beta	p Value	Beta	p Value	Beta	p Value	Beta	p Value
WORMS scale	1.3 (0.03, 2.5)	0.04	−0.2 (−1.4, 0.9)	0.67	0.7 (−0.6, 2.0)	0.28	−0.6 (−1.5, 0.4)	0.24
BLOKS scale	2.7 (1.5, 3.9)	<0.001	0.4 (−1.2, 2.0)	0.60	2.0 (0.8, 3.2)	<0.001	0.4 (−0.8, 1.5)	0.52
BLOKS scale, max baseline BML (area 0–2(n = 46))	−0.4 (−1.7, 0.8)	0.49	0.9 (−0.6, 2.4)	0.25	−0.3 (−1.9, 1.4)	0.76	1.5 (−0.3, 3.26)	0.09
BLOKS scale, max baseline BML (area 3(n = 7))	3.4 (1.4, 5.3)	<0.001	−0.1 (−0.8, 0.7)	0.88	−0.7 (−1.0, −0.5)	<0.001	−0.5 (−1.1, 0.1)	0.10
BLOKS scale, max baseline BML (% of lesion 0–2 (n = 44))	−0.08 (−1.2, 1.0)	0.89	0.7 (−2.5, 4.0)	0.66	0.9 (−0.6, 2.3)	0.24	0.8 (−2.3, 3.9)	0.62
BLOKS scale, max baseline BML (% of lesion 3(n = 9))	4.5 (2.9, 6.2)	<0.001	0.6 (−0.6, 1.9)	0.33	3.9 (0.3, 3.2)	<0.001	−0.7 (−1.3, −0.04)	0.04

BLOKS, Boston–Leeds Osteoarthritis Knee Score; BMI, body mass index; BML, bone marrow lesion; TF, tibiofemoral; WORMS, Whole Organ MRI Score.