Comparison of clinical and genetic criteria of familial Mediterranean fever
| Reference | Study n* | Clinical criteria† | Genetic criterion‡ | Sensitivity (%)§ | Specificity (%)¶ | |
|---|---|---|---|---|---|---|
| Yes | No | |||||
| FMF, familial Mediterranean fever; MEFV, Mediterranean fever; ND, not done. | ||||||
| *n, number in the total population, followed in brackets by the number of patients in the subgroups from (the four mainly affected ethnic groups; patients from other origin). | ||||||
| †Clinical criteria as defined by Livneh. | ||||||
| ‡Genetic criterion as defined by the identification of at least two MEFV mutations. | ||||||
| §Percentage of MEFV-positive patients among those with a clinical FMF. | ||||||
| ¶Percentage of MEFV-negative patients among those negative for the clinical criteria. | ||||||
| Samuels et al2 | 100 (52; 48) | Yes | 24 | 62 | 28 | 100 |
| No | 0 | 14 | ||||
| Tchernitchko et al24 | 208 (0; 208) | Yes | 0 | 208 | 0 | ND |
| No | ND | ND | ||||
| This study | 1574 (752; 822) | Yes | 409 (351; 58) | 709 (235; 474) | 37 (60; 11) | 97 (91.6; 99.7) |
| No | 15 (14; 1) | 441 (152; 289) | ||||