Mean score (standard error of the mean) of semiquantitative analysis (SQA) and digital image analysis (DIA) on six high power fields (HPF) and 60 HPF for interleukin(IL)1β and vascular adhesion molecule (VCAM)-1. Depicted are the paired results for patients with active rheumatoid arthritis and after the achievement of clinical remission and healthy controls
| Active disease (A) | Remission (R) | Controls (C) | A v R (p value) | R v C (p value) | ||
|---|---|---|---|---|---|---|
| IL1β | SQA | 3.0 (0.3) | 1.4 (0.3) | 1.0 (0.2 | <0.005 | NS |
| DIA | ||||||
| 60 HPF | 21 760 (3 733) | 10 446 (3 034) | 4 475 (659) | 0.005 | NS | |
| 20 HPF | 22 291 (3 289) | 10 506 (3 073) | 4 438 (713) | 0.005 | NS | |
| 6 HPF | 26 288 (5 292) | 12 996 (3 993) | 4 504 (741) | <0.01 | NS | |
| VCAM-1 | SQA | 3.1 (0.4) | 2.2 (0.4) | 1.0 (0.3) | NS | <0.05 |
| DIA | ||||||
| 60 HPF | 67 009 (8 503) | 39 674 (9 337) | 11 747 (4 876) | <0.05 | 0.01 | |
| 20 HPF | 68 879 (10 458) | 40 546 (7 749) | 11 966 (4 534) | 0.01 | 0.007 | |
| 6 HPF | 83 409 (12 918) | 45 758 (10 763) | 10 789 (4 494) | <0.05 | 0.005 | |