Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment

Lyna Kamintsky; Steven D Beyea; John D Fisk; Javeria A Hashmi; Antonina Omisade; Cynthia Calkin; Tim Bardouille; Chris Bowen; Maher Quraan; Arnold Mitnitski; Kara Matheson; Alon Friedman; John G Hanly

doi:10.1136/annrheumdis-2020-218004

Article info

Systemic lupus erythematosus

Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment

Authors

Lyna Kamintsky Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Steven D Beyea Biomedical Translational Imaging Centre (BIOTIC), Queen Elizabeth ll Health Sciences Centre, Halifax, Nova Scotia, Canada Diagnostic Radiology, Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
John D Fisk Psychiatry, Psychology & Neuroscience and Medicine, Dalhousie University and Nova Scotia Health Authority, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Javeria A Hashmi Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University and Nova Scotia Health Authority, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Antonina Omisade Acquired Brain Injury (Epilepsy Program), Nova Scotia Health Authority, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Cynthia Calkin Psychiatry and Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada Mood Disorders Clinic, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Tim Bardouille Physics, Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Chris Bowen Biomedical Translational Imaging Centre (BIOTIC), Queen Elizabeth ll Health Sciences Centre, Halifax, Nova Scotia, Canada Diagnostic Radiology, Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Maher Quraan Biomedical Translational Imaging Centre (BIOTIC), Queen Elizabeth ll Health Sciences Centre, Halifax, Nova Scotia, Canada Diagnostic Radiology, Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Arnold Mitnitski Medicine, Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Kara Matheson Research Methods Unit, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Alon Friedman Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada Cognitive and Brain Sciences, Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel PubMed articles Google scholar articles
John G Hanly Medicine and Pathology, Queen Elizabeth ll Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles

Correspondence to Dr John G Hanly, Division of Rheumatology, Nova Scotia Rehabilitation and Arthritis Center, 1341 Summer Street, Queen Elizabeth ll Hlth Svc Ctr, Halifax, NS B3H 4K4, Canada; john.hanly{at}nshealth.ca

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Citation

Kamintsky L, Beyea SD, Fisk JD, et al

Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment

Annals of the Rheumatic Diseases 2020;79:1580-1587.

Publication history

Received May 15, 2020
Revised July 22, 2020
Accepted August 6, 2020
First published October 1, 2020.

Online issue publication

November 13, 2020

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