Footnotes

• Handling editor Josef S Smolen

• Contributors MH, PG and OFG conceived the study, its design, coordination, data interpretation and manuscript drafting and editing.

• Competing interests MH: unrestricted educational grant from AbbVie and Pfizer, and member of advisory boards for AbbVie and Celgene.

• Patient consent for publication Obtained.

• Ethics approval St Vincent’s Healthcare Group Ethics and Medical Research Committee.

• Provenance and peer review Not commissioned; externally peer reviewed.