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Palindromic rheumatism: different genetic background implies a distinct disease entity
  1. S-K Kim1,
  2. H-S Lee2,
  3. K W Lee3,
  4. S-C Bae2,
  5. J-B Jun2
  1. 1Department of Internal Medicine, Division of Rheumatology, College of Medicine, Dankook University, Cheonan, Chungcheong Nam Do, South Korea
  2. 2Department of Internal Medicine, Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, South Korea
  3. 3Hallym Institution for Genome Application, Hallym University Sacred Heart Hospital, Anyang, South Korea
  1. Correspondence to:
    J-B Jun
    Department of Internal Medicine, Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul 133-792, South Korea; junjb@hanyang.ac.kr

https://doi.org/10.1136/ard.2006.052928

    Palindromic rheumatism is characterised by multiple, episodic and recurrent attacks of arthritis, accompanied by periarticular inflammation without residual joint damage, occurring at irregular intervals and lasting from a few hours to several days.1–,3

    The definite pathogenesis and disease entity of palindromic rheumatism has not been clarified until now. We investigated the association of rheumatoid arthritis and palindromic rheumatism with regard to genotype by identifying the distribution of human leucocyte antigen (HLA)-DRB1 alleles in patients with palindromic rheumatism and controls in the Korean population.

    In all, 110 eligible patients with palindromic rheumatism (53 men and 57 women) were recruited. All enrolled patients met our inclusion criteria, which were based on diagnostic features previously described in the literature. …

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    Footnotes

    • Funding: This work was partly supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ3-PG6-01GN11-0002).