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  • Lack of association between signaling lymphocytic activation molecule family member 1 gene and rheumatoid arthritis in the French and Tunisian populations

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Lack of association between signaling lymphocytic activation molecule family member 1 gene and rheumatoid arthritis in the French and Tunisian populations
  1. G Chabchoub1,
  2. E Petit-Teixeira4,
  3. A Maalej1,
  4. C Pierlot2,
  5. Z Bahloul4,
  6. F Cornélis3,
  7. H Ayadi1
  1. 1Laboratoire de Génétique Moléculaire Humaine, Faculté de Médecine de Sfax, Rue Magida Boulila, Tunisia
  2. 2Genhotel Laboratoire de Recherche Européen pour la Polyarthrite Rhumatoïde, Université d’Evry-Val d’Essonne, Paris, France
  3. 3Unité de Génétique Clinique. Hôpital Lariboisière, Assistance publique, Hôpitaux de Paris, Paris
  4. 4Service de Médecine Interne CHU Hédi Chaker Sfax, Sfax, Tunisia
  1. Correspondence to:
    H Ayadi
    Laboratoire de Génétique Moléculaire Humaine, Faculté de Médecine, Avenue Majida Boulila 3029 Sfax, Tunisia; hammadi.ayadi{at}fmsf.rnu.tn

https://doi.org/10.1136/ard.2006.052209

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    Signaling lymphocytic activation molecule family member 1 (SLAMF1) is a member of the CD2 immunoglobulin superfamily, which is expressed in T cells, B cells, macrophages and dendritic cells.1SLAMF1 is associated with B cell proliferation and immunoglobulin synthesis.2 The expression of SLAMF1 in peripheral blood B cells from patients with rheumatoid arthritis was raised compared with healthy controls,3 and high expression of this molecule was observed in synovial fluid and tissue of patients with rheumatoid arthritis. Moreover, mice deficient in the SH2D1A molecule, which binds to the SLAMF1 receptor, were susceptible to experimental autoimmune diseases.4,5 Considering these biological data and the potential role of the SLAMF1 gene in regulating the immune system, we investigated the candidate gene SLAMF1 polymorphism, located on chromosome 1 …

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    Footnotes

    • Funding: AFP, ARP, Association Française des Polyarthritiques, Association de Recherche pour la Polyarthrite, Association Polyarctique, SFR, Genopole (France), Ministère de l’Enseignement Supérieur, Ministère de la Recherche Scientifique et de la Technologie (Tunisa) and the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste (Italy).

    • Competing interests: None declared.