Table 2

Changes in lung function parameters at end of each treatment period compared with baseline

Time of measurements	OD_AM	BD	OD_PM	p-value^†
Improvement in FEV₁ (mL), median (IQR)
04:00 (n=21)	60 (10, 200)	110 (0, 240)	120 (40, 210)	0.33
10:00 (n=21)	40 (−10, 100)	30 (−20, 190)	110 (−20, 200)	0.33
16:00 (n=21)	110 (−30, 200)	100 (50, 260)	80 (−40, 210)	0.72
22:00 (n=21)	−20 (−80, 230)	80 (−20, 200)	160 (70, 270)	<0.01
Improvement in FEV₁ % predicted, median (IQR)
04:00 (n=21)	2 (0, 5)	4 (0, 6)	4 (1, 8)	0.22
10:00 (n=21)	1 (0, 3)	1 (−1, 7)	3 (−1, 5)	0.44
16:00 (n=21)	3 (−1, 8)	2 (2, 7)	3 (−1, 6)	0.85
22:00 (n=21)	0 (−3, 6)	4 (0, 5)	5 (2, 8)	<0.01
Improvement in FVC (mL), median (IQR)
04:00 (n=21)	50 (20, 150)	50 (−50, 270)	100 (0, 230)	0.44
10:00 (n=21)	40 (0, 130)	80 (−20, 190)	150 (−30, 190)	0.50
16:00 (n=21)	20 (−180, 180)	90 (−190, 220)	20 (−70, 130)	0.83
22:00 (n=20)	−35 (−208, 62)	10 (−165, 130)	55 (−80, 198)	0.08
Improvement in FVC % predicted, median (IQR)
04:00 (n=21)	1 (0, 3)	1 (−1, 5)	3 (0, 5)	0.49
10:00 (n=21)	2 (0, 3)	2 (0, 4)	3 (0, 5)	0.33
16:00 (n=21)	1 (−5, 4)	2 (−4, 5)	1 (−1, 3)	0.85
22:00 (n=20)	−1.5 (−5, 2)	0 (−4, 3)	2 (−2, 5)	0.03
Changes in FEV₁/FVC ratio (%), median (IQR)
04:00 (n=21)	0.8 (−0.5, 2.4)	1.5 (−1.4, 5.6)	1.9 (0.8, 2.9)	0.07
10:00 (n=21)	0.1 (−1.1, 1.8)	−0.8 (−2.2, 1.7)	0.1 (−1.3, 3.6)	0.47
16:00 (n=21)	2.1 (0.4, 4.9)	2.0 (0.2, 4.4)	1.2 (−0.2, 3.2)	0.54
22:00 (n=20)	1.4 (−0.7, 4.2)	1.3 (−0.7, 3.9)	3.1 (1.2, 5.1)	<0.05

Bold indicates statistical significance and subsequent pairwise comparison carried out and demonstrated in online supplemental figure 11.
BD, twice a day; FEV₁, forced expiratory volume ins 1 s; FVC, forced vital capacity; OD_AM, once a day in the morning; OD_PM, once a day in the afternoon.