Table 4

Summary of diagnostic indices for Xpert Ultra, smear, culture, cytology and ROSE in EBUS-TBNA samples

EBUS	Xpert Ultra (trace as positive)	Xpert Ultra (trace as negative)	P value*	Smear	P value*	Culture	P value*	Cytology	P value*	ROSE	P value*
Reference standard: culture-positive TB diagnosis (category 1)
Positive tests	12/17	10/17		2/17		17/17		13/15		12/13
Sensitivity	0.71 (0.63 to 0.78)	0.59 (0.54 to 0.63)	0.157	0.12	0.002	1.00 (0.89 to 1.00)	—	0.87 (0.76 to 0.98)	0.257	0.92 (0.78 to 1.00)	0.103
Specificity	0.99 (0.97 to 1.00)	0.99 (0.97 to 1.00)		1.00 (0.98 to 1.00)		1.00 (0.98 to 1.00)		0.67 (0.67 to 0.68)		0.42
PPV	0.92 (0.78 to 1.00)	0.91 (0.75 to 1.00)		1.00 (0.02 to 1.00)		1.00 (0.88 to 1.00)		0.29		0.32
NPV	0.95 (0.93 to 0.97)	0.93 (0.92 to 0.95)		0.87 (0.85 to 0.88)		1.00 (0.98 to 1.00)		0.97 (0.94 to 1.00)		0.95 (0.85 to 1.00)
Reference standard: clinical diagnosis of TB—culture-confirmed TB (category 1) and highly probable TB (category 2)
Positive tests	15/26	10/26		2/26		17/26		19/24		16/20
Sensitivity	0.58 (0.55 to 0.61)	0.39	0.025	0.07	0.0003	0.65 (0.61 to 0.70)	0.480	0.79 (0.73 to 0.86)	0.083	0.80 (0.72 to 0.88)	0.020
Specificity	0.99 (0.97 to 1.00)	0.99 (0.97 to 1.00)		1.00 (0.98 to 1.00)		1.00 (0.98 to 1.00)		0.67 (0.66 to 0.68)		0.42
PPV	0.94 (0.82 to 1.00)	0.91 (0.75 to 1.07)		1.00 (0.02 to 1.00)		1.00 (0.88 to 1.00)		0.37		0.39
NPV	0.90 (0.88 to 0.92)	0.86 (0.85 to 0.87)		0.80 (0.79 to 0.82)		0.92 (0.90 to 0.93)		0.93 (0.90 to 0.95)		0.82 (0.75 to 0.89)

*Comparing sensitivity versus Xpert Ultra (trace as positive)—with Bonferroni correction factor.
EBUS-TBNA, endobronchial ultrasound-guided transbronchial needle aspiration; NPV, negative predictive value; PPV, positive predictive value; ROSE, rapid on-site evaluation of cytology; TB, tuberculosis.