Correlations between eosinophil and inflammatory markers in asthmatics
| TNF-alpha | IL-8 | IL-5 | IL-7 | IL-10 | IL-1Ra | IL-13 | Leptin | hs-CRP | FENO | ||
| ECP | R 95% CI p value n | 0.140 (0.031 to 0.245) 0.03 322 | 0.162 (0.054 to 0.267) 0.02 322 | 0.157 (0.49 to 0.262) 0.02 322 | 0.167 (0059 to 0.271) 0.01 322 | 0.078 (−0.032 to 0.185) 0.33 322 | 0.079 (−0.031 to 0.187) 0.34 322 | 0.152 (0.043 to 0.257) 0.03 322 | 0.053 (−0.057 to 0.161) 0.95 322 |
0.190
(0.086 to 0.289) 0.0002 344 |
0.248
(0.122 to 0.366) 0.0002 228 |
| EDN | R 95% CI p value n | 0.156 (0.047 to 0.260) 0.009 322 | 0.123 (0.014 to 0.229) 0.04 322 | 0.144 (0.035 to 0.249) 0.02 322 | 0.155 (0.047 to 0.260) 0.007 322 | 0.120 (0.011 to 0.226) 0.03 322 | 0.098 (−0.011 to 0.205) 0.14 322 |
0.182
(0.074 to 0.285) 0.001 322 | −0.071 (−0.179 to 0.039) 0.18 322 | 0.030 (−0.076 to 0.135) 0.11 344 |
0.372
(0.254 to 0.478) <0.0001 228 |
Correlation coefficients (R) were computed using Pearson’s test after log transformation of marker concentrations (ECP, EDN and CRP) or human serum pool ratio (TNF-alpha, IL-8, IL-5, IL-7, IL-10, IL-1Ra, IL-13, leptin). P values were adjusted on age, sex, smoking status and BMI and took into account familial dependence. ‘n’ indicates the number of samples available for each biomarker. Bold indicates statistically significant differences after Bonferroni’s multiple test correction (threshold p value=0.0025)
ECP, eosinophil cationic protein; EDN, eosinophil-derived neurotoxin; hs-CRP, high-sensitivity C reactive protein; IL, interleukin; TNF, tumour necrosis factor.