Quality of life and mood outcomes
| Time (weeks) | Air mean (SD) | Oxygen mean (SD) | ANOVA: p Values | ||||
| Treatment | Time | Interaction | |||||
| CRDQ* | Dyspnoea | Baseline | 17.5 (4.9) | 17.6 (5.2) | 0.439 | <0.001 | 0.843 |
| Range: 5–35 | 4 | 18.4 (5.8) | 19.7 (5.4) | ||||
| MID: 2.5 | 12 | 18.4 (5.9) | 19.5 (6.0) | ||||
| Fatigue | Baseline | 15.2 (4.1) | 15.3 (5.0) | 0.846 | 0.076 | 0.837 | |
| Range: 4–28 | 4 | 15.9 (4.8) | 16.1 (5.3) | ||||
| MID: 2.0 | 12 | 15.7 (5.3) | 15.5 (5.1) | ||||
| Emotion | Baseline | 33.8 (8.1) | 35.1 (8.0) | 0.570 | 0.861 | 0.694 | |
| Range: 7–49 | 4 | 34.0 (7.5) | 35.6 (8.6) | ||||
| MID: 3.5 | 12 | 34.3 (8.2) | 34.5 (9.7) | ||||
| Mastery | Baseline | 19.7 (4.5) | 19.7 (4.7) | 0.585 | 0.696 | 0.436 | |
| Range: 4–28 | 4 | 19.4 (4.8) | 20.6 (4.6) | ||||
| MID: 2.0 | 12 | 19.8 (5.4) | 20.2 (5.2) | ||||
| Total score | Baseline | 86.3 (16.6) | 87.7 (18.4) | 0.596 | 0.054 | 0.912 | |
| Range: 20–140 | 4 | 87.6 (18.3) | 92.0 (19.9) | ||||
| MID: 10 | 12 | 88.2 (20.5) | 89.6 (22.6) | ||||
| AQoL* | Utility score | Baseline | 0.52 (0.26) | 0.52 (0.26) | 0.661 | 0.100 | 0.414 |
| Range: −0.04–1.0 | 4 | 0.52 (0.24) | 0.52 (0.26) | ||||
| MID: 0.06 | 12 | 0.57 (0.27) | 0.52 (0.27) | ||||
| HADS† | Anxiety | Baseline | 5.7 (4.1) | 5.3 (4.2) | 0.678‡ | 0.083 | 0.970 |
| Range: 0–21 | 4 | 5.4 (3.7) | 5.1 (4.3) | ||||
| 12 | 5.4 (3.9) | 5.4 (4.6) | |||||
| Depression | Baseline | 5.4 (2.8) | 5.8 (3.6) | 0.981 | <0.001 | 0.203 | |
| Range: 0–21 | 4 | 5.1 (3.0) | 4.9 (3.4) | ||||
| 12 | 5.1 (3.4) | 4.9 (3.5) | |||||
↵* Higher scores represent better quality of life.
↵† Higher scores represent more anxiety or depression.
↵‡ ANOVA used square-root transformation.
ANOVA, analysis of variance; AQoL, Assessment of Quality of Life questionnaire; CRDQ, Chronic Respiratory Disease Questionnaire; HADS, Hospital Anxiety and Depression Scale, ≥10=clinically significant Anxiety and/or Depression; MID, minimal important difference; Range, highest and lowest scores able to be obtained on each of the tests.