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Safety and tolerability of three consecutive bronchoscopies after allergen challenge in volunteers with mild asthma
  1. H H Kariyawasam1,
  2. M Aizen1,
  3. A Barry Kay2,
  4. D S Robinson3
  1. 1Department of Allergy and Clinical Immunology, Leukocyte Biology Section, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
  2. 2Leukocyte Biology Section, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
  3. 3Department of Allergy and Clinical Immunology, Leukocyte Biology Section, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
  1. Correspondence to:
    Professor A Barry Kay
    Sir Alexander Fleming Building, Leukocyte Biology Section, Imperial College London, South Kensington Campus, London SW7 2AZ, UK; a.b.kay{at}imperial.ac.uk

https://doi.org/10.1136/thx.2006.073775

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    Ethical and safety considerations limit the design of studies with more than two consecutive fibreoptic bronchoscopies (FOBs) in patients with asthma. We present data on the safety and tolerability of three consecutive bronchoscopies at baseline, and 24 h and 7 days after allergen provocation. The study included 15 volunteers with mild asthma (9 men and 6 women); median age 25 (range 19–46) years; percentage predicted forced expiratory volume in 1 s (FEV1) 97% (range 75.4–125.7%); and a mean provocative concentration of methacholine causing a 20% fall in FEV1 (PC20) of 2.1 (95% confidence interval (CI) 1.2 to 3.6) mg/ml at baseline FOB, 0.93 (95% CI 0.38 to 2.2) mg/ml at 24 h (p = 0.08) and 0.90 (95% CI 0.45 to 1.8) mg/ml at 7 days (p = 0.03) after the …

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    Footnotes

    • Funding: This study was sponsored by the Imperial College Trust Fund.

    • Competing interests: None declared.