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Case Report
Disseminated Mycobacterium tuberculosis infection due to interferon γ deficiency. Response to replacement therapy
  1. Suranjith Luke Seneviratne1,*,
  2. Rainer Doffinger2,*,
  3. John Macfarlane4,
  4. L Ceron-Gutierrez3,
  5. M R Amel Kashipaz1,
  6. A Robbins1,
  7. T Patel1,
  8. P T Powell1,
  9. D S Kumararatne2,
  10. Richard J Powell1
  1. 1Clinical Immunology Unit, Queens Medical Centre, Nottingham, UK
  2. 2Department of Immunology, Addenbrookes Hospital, Cambridge, UK
  3. 3Department of Clinical Biochemistry and Immunology, Addenbrookes Hospital, Cambridge, UK
  4. 4Respiratory Medicine Department, Nottingham City Hospital, Nottingham, UK
  1. Correspondence to:
    Dr Suranjith Luke Seneviratne
    Department of Clinical Immunology, Manchester Royal Infirmary Manchester M13 9WL, UK; suran200{at}yahoo.co.uk

Abstract

The case of a previously healthy HIV seronegative woman with disseminated Mycobacterium tuberculosis infection and markedly reduced interferon γ production is reported here. Complete healing of her disseminated lesions was seen only after addition of subcutaneous interferon γ to her tuberculosis treatment.

  • IFN, interferon

https://doi.org/10.1136/thx.2005.051649

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    Footnotes

    • ↵* These authors contributed equally to this paper.

    • Competing interests: None declared.

    • Informed consent has been obtained from the patient for publication of her details in this paper.