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Abstract
A wide range of adjuvant treatments have been studied to treat osteonecrosis. Photobiomodulation and photodynamic therapy are commonly used. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review was conducted to evaluate photobiomodulation and photodynamic therapy for the treatment of osteonecrosis related to the use of medications or related to ionising radiation. After searching PubMed, EMBASE, LILACS and Livivo Database, 2 systematic reviews, 4 prospective comparative studies, 10 comparative studies and 23 retrospective case reports were selected. Photobiomodulation-positive outcomes were observed in pain management and healing linked to osteonecrosis of the jaw due to antiresorptive drugs. Limited studies exist on photodynamic therapy and osteoradionecrosis. No adverse effects were reported. Despite the low quality of evidence, findings suggest that photobiomodulation may serve as an adjuvant therapy for osteoporotic patients, particularly those ineligible for surgery. Similar benefits were noted for oncological patients, but controlled trials evaluating cancer-related outcomes are lacking, emphasising the need for further research.
- Bone
- Complementary therapy
- Pain
- Quality of life
- Supportive care
Data availability statement
All data relevant to the study are included in the article or uploaded as supplementary information.
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Data availability statement
All data relevant to the study are included in the article or uploaded as supplementary information.
Footnotes
Contributors RAB: conceptualisation, methodology, data acquisition, formal analysis, writing–review and editing. GBB: investigation, formal analysis, data acquisition, writing–review and editing; RP-A: investigation, formal analysis, data acquisition, writing–review and editing; PBRdO: resources, writing–review and editing, validation; TBdS: resources, writing–review and editing, validation; RLM: resources, writing–review and editing; validation. AL-d-S-F: resources, writing–review and editing, validation. MFSDR: conceptualisation, methodology, resources, writing–review and editing; conceptualisation, validation. LRB: resources, writing–review and editing; conceptualisation, validation. RBC: conceptualisation, methodology, data curation, supervision, resources, validation, writing–original draft, writing–review and editing, project administration. RBC is the guarantor author. All authors reviewed and approved the final version of manuscript.
Funding The author Rodrigo Antico Benetti received funding from Programa de Excelência Acadêmica (PROEX) da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)/Brazil—number 33092010013P4 without any influence on the impartial conduct of the research.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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