The percentage of ceftaroline concentration remaining in the elastomeric pumps stored at various temperatures for different time intervals. Results are presented as mean±SD
Time (hours) | % Initial drug concentration remaining (mean±SD) | |||||||
4°C | 25°C | 30°C | 35°C | |||||
NS | Glucose 5% | NS | Glucose 5% | NS | Glucose 5% | NS | Glucose 5% | |
0.5 | - | - | 97.7±0.4 | 98.9±0.6 | 98.9±0.5 | 99.9±0.5 | 99.7±0.5 | 98.9±0.2 |
1 | - | - | 99.6±0.6 | 98.5±0.7 | 98.5±0.4 | 99.7±0.5 | 99.3±1.1 | 97.7±0.6 |
2 | 99.7±0.5 | 99.8±0.9 | 99.6±0.7 | 97.5±0.5 | 98.4±0.2 | 98.1±0.4 | 99.3±0.2 | 96.6±0.3 |
6 | 99.6±0.4 | 101±0.3 | 98.1±0.8 | 96.4±0.4 | 96.9±0.5 | 94.4±0.8 | 96.1±0.4 | 92.4±0.2 |
12 | - | - | 95.2±0.2 | 93.0±0.2 | 94.8±0.5 | 90.9±0.2 | 94.3±0.8 | 80.2±0.3 |
24 | 98.9±0.2 | 100±0.8 | 90.1±0.1 | 90.2±0.2 | 85.0±0.2 | 80.9±0.5 | 87.3±0.4 | 70.2±0.3 |
48 | 98.8±0.3 | 100±0.5 | - | - | - | - | - | - |
72 | 98.3±0.5 | 99.8±0.4 | - | - | - | - | - | - |
96 | 98.5±0.5 | 100±0.5 | - | - | - | - | - | - |
120 | 98.6±0.3 | 100±0.5 | - | - | - | - | - | - |
144 | 98.4±0.5 | 101±0.9 | - | - | - | - | - | - |
NS, Normal saline.