Pathological changes of nerve biopsy
| Patients | 1 | 3 | 5 |
|---|---|---|---|
| H&E and LFB (8 μ sections) | |||
| Oedema | − | − | − |
| Vessel constructure | Normal | Normal | Normal |
| Inflammatory cell infiltration | − | − | − |
| Connective tissue proliferation | − | − | − |
| Loss of myelinated axons | Moderate | Moderate | NO |
| Axonal degeneration | + | + | − |
| Demyelination | − | − | + |
| Onionoid structure | − | − | − |
| Congo red stain (8 μ sections) | − | − | − |
| Toluidine blue Stain (semithin) | |||
| Vessels constructure | Normal | Normal | Normal |
| Inflammatory cell infiltration | − | − | − |
| Abnormal deposition | − | − | − |
| Connective tissue proliferation | − | − | − |
| Loss of myelinated axons | Moderate | Moderate | NO |
| Axonal degeneration | + | + | − |
| Demyelination | − | − | + |
| Regeneration | + | + | − |
| Onionoid structure | − | − | − |
| Loss of unmyelinated nerve | − | + | − |
LFB, Luxol Fast Blue.