Table 2

Pathological features of muscle biopsy

Patients	1	2	3	4	5	6
Connective tissue proliferation	–	+	–	–	+	–
Myonecrosis (H&E)	–	–	–	+	–	–
Regeneration	+	+	+	+	+	+
Vacuoles	+	+	–	–	–	–
Nuclear internalisation	+	+	–	–	+	+
Muscle fibre
Fibre diameter	Bimodal	Bimodal	Bimodal	Unimodal	Unimodal	Unimodal
Hypertrophy fibre	+	+	+	+	+	–
small round fibre	–	–	–	–	+	–
Angulated fibre	+	+	+	+	+	+
Grouped angulated fibre	+	+	+	–	+	–
PAS	–	–	–	+	+	–
ORO	+	+	+	+	–	+
Mitochondrial change
Raged red fibres (MGT)	+	+	+	+	–	+
NADH-TR enzyme activity change	+	+	–	–	+	–
COX-negative fibres (COX)	+	+	+	+	+	+
Ragged blue fibres (SDH)	+	+	+	+	–	+
Type I fibre atrophy (ATPase)	+	–	+	+	+	+
Type I fibre hypertrophy (ATPase)	+	–	–	+	+	–
Type II fibre atrophy (ATPase)	+	+	+	+	+	+
Type II fibre hypertrophy (ATPase)	–	+	–	+	+	–
Vessels structure	Normal	Normal	Normal	Normal	Normal	Normal
Inflammatory cell infiltration	–	+	–	+	–	–

ATPase, adenosine triphosphatase; COX, cytochrome c oxidase; MGT, modified Gomori trichrome; ORO, oil red O staining; PAS, periodic acid Schiff staining; SDH, succinate dehydrogenase.