RT Journal Article
SR Electronic
T1 Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 520
OP 524
DO 10.1136/bjophthalmol-2017-310477
VO 102
IS 4
A1 Spain, Rebecca I
A1 Liu, Liang
A1 Zhang, Xinbo
A1 Jia, Yali
A1 Tan, Ou
A1 Bourdette, Dennis
A1 Huang, David
YR 2018
UL http://bjo.bmj.com/content/102/4/520.abstract
AB Background Quantitative assessment of optic nerve damage is important in the evaluation of optic neuritis (ON) and multiple sclerosis (MS).Objective To detect optic nerve damage using optical coherence tomography (OCT) and OCT angiography in MS.Methods Peripapillary retinal nerve fibre layer (NFL) thickness, macular ganglion cell complex (GCC) thickness and Optic Nerve Head Flow Index (ONH-FI) were measured. The ONH-FI was defined as flow signal averaged over the optic disc. Diagnostic accuracy was evaluated by the area under the receiver-operating characteristics curve (AROC).Results Sixty-eight eyes of 45 MS participants and 55 eyes of 32 healthy controls (HCs) were analysed. Of MS eyes, 25 had a history of ON (MS+ON) and 43 didn’t (MS−ON). MS−ON and MS+ON eyes had reductions in ONH-FI (p=0.031 and p=0.001, respectively), GCC thickness (p=0.245 and p<0.001, respectively), and NFL thickness (p=0.003 and p=0.024, respectively), compared with HCs. The highest AROC (0.940) was achieved by the logistic regression combination of all three variables, which was significantly higher than other variables (p=0.018).Conclusion MS produces both retinal structural loss and decreased ONH perfusion in MS eyes with and without history of ON. The combination of perfusion and structural measurements enhances detection of optic nerve damage in MS. OCT angiography may be a useful additional retinal marker in evaluation of ON in MS.