PT  - JOURNAL ARTICLE
AU  - Muqit, M M K
AU  - Gray, J C B
AU  - Marcellino, G R
AU  - Henson, D B
AU  - Young, L B
AU  - Charles, S J
AU  - Turner, G S
AU  - Stanga, P E
TI  - Fundus autofluorescence and Fourier-domain optical coherence tomography imaging of 10 and 20 millisecond Pascal retinal photocoagulation treatment
AID  - 10.1136/bjo.2008.148833
DP  - 2009 Apr 01
TA  - British Journal of Ophthalmology
PG  - 518--525
VI  - 93
IP  - 4
4099  - http://bjo.bmj.com/content/93/4/518.short
4100  - http://bjo.bmj.com/content/93/4/518.full
SO  - Br J Ophthalmol2009 Apr 01; 93
AB  - Aim: To report the evolution of pattern scanning laser (Pascal) photocoagulation burns in the treatment of diabetic retinopathy, using Fourier-domain optical coherence tomography (FD-OCT) and fundus autofluorescence (AF), and to evaluate these characteristics with clinically visible alterations in outer retina (OR) and retinal pigment epithelium (RPE).Methods: Standard red-free and colour fundus photography (FP), FD-OCT, and fundus camera-based AF were performed in 17 eyes of 11 patients following macular and panretinal photocoagulation (PRP).Results: One hour following Pascal application, visibility of threshold burns on FP was incomplete. AF enabled visualisation of complete treatment arrays at 1 h, with hypoautofluorescence at sites of each laser burn. AF signals accurately correlated with localised increased optical reflectivity within the outer retina on FD-OCT. AF signals became hyperautofluorescent at 1 week, and corresponded on FD-OCT to defects at the junction of the inner and outer segments of the photoreceptors (JI/OSP) and upper surface of RPE. A 10 ms macular laser pulse produced a localised defect at the level of JI/OSP and RPE. Macular and 20 ms PRP burns did not enlarge at 1 year’s and 18 months’ follow-up respectively.Conclusions: We report the in vivo spatial localisation and clinical correlation of medium-pulse Pascal photocoagulation burns within outer retina and RPE, using high-resolution FD-OCT and AF. Ophthalmoscopically invisible and threshold Pascal burns may be accurately localised and mapped by AF and FD-OCT, with monitoring over time.