Myeloid-derived suppressor cell - MDSC

METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation
Yonghua Tong, Zhiqiang Chen, Jian Wu, Qiu Huang, Yu He, Haojie Shang, Ding Xia, Ejun Peng, Zhihua Wang, Xiaoyu Liang, Kun Tang

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011108; DOI: 10.1136/jitc-2024-011108
Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma
Qian Sun, Nina Wang, Juliane Poelchen, Mareike Peter, Daniel Novak, Feyza Gül Özbay Kurt, Rebekka Bitsch, Huizi Wu, Yiman Wang, Sandra Pardo, Rui Han, Shibo Liu, Lidong Gong, Yuxin Zhang, Kilian Wistuba-Hamprecht, Viktor Umansky, Jochen Sven Utikal

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010352; DOI: 10.1136/jitc-2024-010352
Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer
Oladapo O Yeku, Minal Barve, Winston W Tan, Judy Wang, Amita Patnaik, Patricia LoRusso, Debra L Richardson, Abdul Rafeh Naqash, Sarah K Lynam, Siqing Fu, Michael Gordon, Joleen Hubbard, Shivaani Kummar, Christos Kyriakopoulos, Afshin Dowlati, Marc Chamberlain, Ira Winer

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010959; DOI: 10.1136/jitc-2024-010959
Targeted inhibition of Aurora kinase A promotes immune checkpoint inhibition efficacy in human papillomavirus-driven cancers
Soma Ghosh, Madison P O'Hara, Pragya Sinha, Tuhina Mazumdar, Lacin Yapindi, Jagannadha K Sastry, Faye M Johnson

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e009316; DOI: 10.1136/jitc-2024-009316
Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors
Wei Xiong, Liuling Xiao, Rui Duan, Qiang Wang, Miao Xian, Chuanchao Zhang, Pan Su, Yabo LI, Ling Zhong, Jianfei Qian, Chengyun Zheng, Qing Yi

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e008979; DOI: 10.1136/jitc-2024-008979
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling
Feyza Gül Özbay Kurt, Beatrice-Ana Cicortas, Bianca M Balzasch, Carolina De la Torre, Volker Ast, Ece Tavukcuoglu, Cagla Ak, Sebastian A Wohlfeil, Adelheid Cerwenka, Jochen Utikal, Viktor Umansky

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (9) e009552; DOI: 10.1136/jitc-2024-009552
Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases
Chandra C Ghosh, Lauren Cournoyer, Yujia Liu, Alizee Ballarin, Ilan B Layman, Jason LaPorte, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha, Prajna Guha, Steven C Katz, Diwakar Davar

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e008837; DOI: 10.1136/jitc-2024-008837
Sequence of androgen receptor-targeted vaccination with androgen deprivation therapy affects anti-prostate tumor efficacy
Anusha Muralidhar, Melissa Gamat-Huber, Sita Vakkalanka, Douglas G McNeel

Journal for ImmunoTherapy of Cancer May 2024, 12 (5) e008848; DOI: 10.1136/jitc-2024-008848
Myeloid-derived suppressor cells attenuate the antitumor efficacy of radiopharmaceutical therapy using ⁹⁰Y-NM600 in combination with androgen deprivation therapy in murine prostate tumors
Anusha Muralidhar, Reinier Hernandez, Zachary S Morris, Hansel Comas Rojas, Malick Bio Idrissou, Jamey P Weichert, Douglas G McNeel

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008760; DOI: 10.1136/jitc-2023-008760

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Myeloid-derived suppressor cell - MDSC