Hematologic malignancies

Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing
Minjing Wang, Joshua B Krueger, Alexandria K Gilkey, Erin M Stelljes, Mitchell G Kluesner, Emily J Pomeroy, Joseph G Skeate, Nicholas J Slipek, Walker S Lahr, Patricia N Claudio Vázquez, Yueting Zhao, Jason B Bell, Kendell Clement, Ella J Eaton, Kanut Laoharawee, Jae-Woong Chang, Beau R Webber, Branden S Moriarity

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e009560; DOI: 10.1136/jitc-2024-009560
CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukemia progression
Javier Arroyo-Ródenas, Aida Falgas, Laura Díez-Alonso, Alba Martinez-Moreno, Heleia Roca-Ho, Francisco J. Gil-Etayo, Alba Pérez-Pons, Óscar Aguilar-Sopeña, Miriam Velasco-Sidro, Marina Gómez-Rosel, Beatriz Jiménez-Matías, Guillermo Muñoz-Sánchez, Yedra Pacheco, Clara Bravo-Martín, Ángel Ramírez-Fernández, Anaïs Jiménez-Reinoso, Europa Azucena González-Navarro, Manel Juan, Alberto Orfao, Belén Blanco, Pedro Roda-Navarro, Clara Bueno, Pablo Menéndez, Luis Álvarez-Vallina

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e009048; DOI: 10.1136/jitc-2024-009048
JAK3 ^A573V and JAK3 ^M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway
Ning Lou, Mengwei Yang, Zucheng Xie, Ruyun Gao, Lei Zhang, Le Tang, Jiarui Yao, Xiaohong Han, Yuankai Shi

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010783; DOI: 10.1136/jitc-2024-010783
First reported case of a spontaneous and healthy pregnancy in a woman with persistent CAR T-cells 5 years after treatment for diffuse large B-cell lymphoma
Ethan Abraham Canty, Lori Broderick, Daniel Flaherty, Marin Xavier, Sunita D Nasta, Lina Dajani, Andrew A White

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011092; DOI: 10.1136/jitc-2024-011092
Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry
Daniel J Landsburg, Matthew J Frigault, Michael Heim, Stephen Ronan Foley, Brian Hill, Grant Schofield, Caron A Jacobson, Samantha Jaglowski, Frederick L Locke, Ron Ram, Peter A Riedell, Gunjan Shah, Leslie L Popplewell, Ranjan Tiwari, Stephen Lim, Marta Majdan, Aisha Masood, Marcelo Pasquini, Cameron J Turtle

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e009890; DOI: 10.1136/jitc-2024-009890
Blocking the CD39/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphoma
Clara Kolbe, Joseph Kauer, Berit Brinkmann, Peter Dreger, Wolfgang Huber, Carsten Müller-Tidow, Sascha Dietrich, Tobias Roider

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e009245; DOI: 10.1136/jitc-2024-009245
Chemotherapy-induced cellular senescence promotes stemness of aggressive B-cell non-Hodgkin’s lymphoma via CCR7/ARHGAP18/IKBα signaling activation
Jiyu Wang, Qianshan Tao, Keke Huang, Yangyang Wang, Linhui Hu, Anwen Ren, Huiping Wang, Yang Wan, Jinlan Li, Liuying Yi, Yanjie Ruan, Zhixiang Wanyan, Fan Wu, Zhimin Zhai, Chaohong Liu

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e009356; DOI: 10.1136/jitc-2024-009356
Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors
Wei Xiong, Liuling Xiao, Rui Duan, Qiang Wang, Miao Xian, Chuanchao Zhang, Pan Su, Yabo LI, Ling Zhong, Jianfei Qian, Chengyun Zheng, Qing Yi

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e008979; DOI: 10.1136/jitc-2024-008979
DNA barcoded peptide-MHC multimers to measure and monitor minor histocompatibility antigen-specific T cells after allogeneic stem cell transplantation
Kyra J Fuchs, Marcus Göransson, Michel G D Kester, Natasja W Ettienne, Marian van de Meent, Rob C M de Jong, Eva A S Koster, Constantijn J M Halkes, Ferenc Scheeren, Mirjam H M Heemskerk, Peter van Balen, J H Frederik Falkenburg, Sine R Hadrup, Marieke Griffioen

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009564; DOI: 10.1136/jitc-2024-009564
Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma
Fabian Ullrich, Paul J Bröckelmann, Amin T Turki, Abdullah M Khan, Elena-Diana Chiru, Marcus Vetter, Bastian von Tresckow, Rainer Wirth, Raul Cordoba, Valentín Ortiz-Maldonado, Tamas Fülöp, Nina Rosa Neuendorff

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009462; DOI: 10.1136/jitc-2024-009462

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