Table of contents

Clinical/translational cancer immunotherapy

• Original research: Systemic immunomodulation by irreversible electroporation versus stereotactic ablative body radiotherapy in locally advanced pancreatic cancer: the CROSSFIRE trial (26 March, 2025)

  Bart Geboers, Florentine Timmer, Danielle Vos, Hester Scheffer, Joyce Bakker, Alette Ruarus, Laurien Vroomen, Anita Stam, Sinéad Lougheed, Evelien Schouten, Robbert Puijk, Petrousjka van den Tol, Frank Lagerwaard, Jan de Vries, Anna Bruynzeel, Martijn Meijerink, Tanja de Gruijl
• Original research: mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumors (25 March, 2025)

  Henry G Withers, Junko Matsuzaki, Mark Long, Spencer R Rosario, Thinle Chodon, Takemasa Tsuji, Richard Koya, Li Yan, Jianming Wang, Tibor Keler, Shashikant B Lele, Emese Zsiros, Amit Lugade, Alan Hutson, Stephanie Blank, Nina Bhardwaj, Protul Shrikant, Song Liu, Kunle Odunsi
• Cardiac MRI study of adverse events in patients treated with immune checkpoint inhibitors: a prospective cohort study of cardiac adverse events (18 March, 2025)

  Agnese Losurdo, Cristina Panico, Chiara Catalano, Simone Serio, Laura Giordano, Lorenzo Monti, Federica Catapano, Stefano Figliozzi, Carla D’Andrea, Angelo Dipasquale, Pasquale Persico, Antonio Di Muzio, Marco Cremonesi, Alessandro Marchese, Maria Chiara Tronconi, Matteo Perrino, Giovanna Finocchiaro, Enrico Lugli, Marco Francone, Armando Santoro, Gianluigi Condorelli, Matteo Simonelli, Marinos Kallikourdis
• Original research: Nivolumab adjuvant to chemo-radiation in localized muscle-invasive urothelial cancer: primary analysis of a multicenter, single-arm, phase II, investigator-initiated trial (NEXT) (18 March, 2025)

  Gliceida M. Galarza Fortuna, Daniel Grass, Benjamin L Maughan, Rohit K Jain, Christopher Dechet, Julia Beck, Ekke Schuetz, Alejandro Sanchez, Brock O’Neil, Michael Poch, Roger Li, Shane Lloyd, Jonathan Tward, Tenzin Phunrab, Josiah Lyn Hawks, Umang Swami, Kenneth M Boucher, Neeraj Agarwal, Sumati Gupta
• Original research: New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma (17 March, 2025)

  Noémie Joalland, Agnès Quéméner, Sophie Deshayes, Romain Humeau, Mike Maillasson, Héloïse LeBihan, Apolline Salama, Judith Fresquet, Séverine Remy, Erwan Mortier, Christophe Blanquart, Carole Guillonneau, Ignacio Anegon
• Original research: Phase 2 study of neoadjuvant durvalumab plus docetaxel, oxaliplatin, and S-1 with surgery and adjuvant durvalumab plus S-1 for resectable locally advanced gastric cancer (13 March, 2025)

  Yoon-Koo Kang, Hyung-Don Kim, Hyungwoo Cho, Young Soo Park, Jong Seok Lee, Min-Hee Ryu
• Original research: Leveraging T cell co-stimulation for enhanced therapeutic efficacy of trispecific antibodies targeting prostate cancer (13 March, 2025)

  Yanping Sun, Linling Zhou, Xinyu Gu, Jiaqi Zhao, Jie Bi, Liqiang Pan
• Original research: Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cancer (6 March, 2025)

  Hyein Jeong, Jaemoon Koh, Sehui Kim, Jeemin Yim, Seung Geun Song, Hanbyeol Kim, Yingying Li, Soo Hyun Lee, Yeon Kyu Chung, Hongsoon Kim, Chul-Hwan Lee, Hye Young Kim, Bhumsuk Keam, Se-Hoon Lee, Doo Hyun Chung, Yoon Kyung Jeon
• Original research: Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study (3 March, 2025)

  Amin H Nassar, Sarah Abou Alaiwi, Talal El Zarif, Ryan Denu, Walid Macaron, Noha Abdel-Wahab, Dory Freeman, Alexi Vasbinder, Salim Hayeck, Elizabeth Anderson, Rachel S Goodman, Douglas B Johnson, Shirly Grynberg, Ronnie Shapira, Jennifer M Kwan, Rachel Woodford, Georgina V Long, Tarek Haykal, Susan Dent, Yuki Kojima, Kan Yonemor, Ankita Tandon, Alexandra Trevino, Nausheen Akhter, Eric H Yang, Gavin Hui, Alexandra Drakaki, Edward El-Am, Elie Kozaily, Ahmad Al-Hader, Elias Bou Farhat, Priyanka Babu, Arjun Mittra, Mingjia Li, Nicholas Jones, Javier Baena, Mercedes Juarez Herrera, Simone Foderaro, Frank Aboubakar Nana, Chul Kim, Paul Sackstein, Kaushal Parikh, Aakash P Desai, Caleb Smith, Alessio Cortellini, David J Pinato, James Korolewicz, Nerea Lopetegui-Lia, Pauline Funchain, Arrush Choudhary, Aarti Asnani, Vishal Navani, Daniel Meyers, Igor Stukalin, Jesus Antonio Ocejo Gallegos, Jonathan Trent, Sanober Nusrat, Carmel Malvar, Rana R McKay, Tomas G Neilan, Toni K Choueiri, Abdul Rafeh Naqash