The experiment in general and gross post mortem findings
No | Treatment at n weeks | Sacrifice (months) | Comment |
57 | 2 | 0 | Died postoperative day 1, certainly from device. Old balloon ruptured during treatment causing loss of Neucrylate into left carotid artery |
19 | 5 | 2 | Aneurysm grew following satisfactory treatment |
20 | 5 | 2 | Incomplete filling. Remained stable |
22 | 5 | 2 | Incomplete filling. Remained stable |
24 | 5 | 2 | Satisfactory treatment. Aneurysm continued to grow |
25 | 5 | 2 | Two injections. Aneurysm continued to grow |
59 | 2 | 5 | Only 50% fill during first therapy. Satisfactory retreatment at 5 months. Died following day from gastric rupture |
45 | 7 | 9 | Incomplete treatment. Aneurysm stable at 9 months. Sacrificed because of anorexia/liver failure |
32 | 9 | 12 | Satisfactory treatment. Aneurysm continued to grow |
34 | 7 | 12 | 2 mm aneurysm, satisfactory treatment. Aneurysm continued to grow |
56 | 2 | 12 | Satisfactory treatment. Aneurysm continued to grow |
46 | 7 | 24 | 95% fill. Stable at 2 years |
60 | 2 | 24 | 90% fill. Stable at 2 years |
62 | 2 | 24 | 50% fill at first treatment. Retreatment at 5 months. Fusiform dilatation of parent artery (some regrowth) |
Other rabbits—23 (anesthetic death), 31 (viral illness), 33 (anorexia), 35 (gastric perforation) and 61 (stroke/sacrificed) died following aneurysm induction but before treatment. Subsequently, all rabbits were pretreated with alkali and a proton pump inhibitor in an attempt to decrease the stress of anesthesia and operation. Column 2 indicates the number of weeks after aneurysm induction that treatment was carried out.