RT Journal Article
SR Electronic
T1 Mechanical thrombectomy and rescue therapy for intracranial large artery occlusion with underlying atherosclerosis
JF Journal of NeuroInterventional Surgery
JO J NeuroIntervent Surg
FD BMJ Publishing Group Ltd.
SP 746
OP 750
DO 10.1136/neurintsurg-2017-013489
VO 10
IS 8
A1 Jia, BaiXue
A1 Feng, Lei
A1 Liebeskind, David S
A1 Huo, Xiaochuan
A1 Gao, Feng
A1 Ma, Ning
A1 Mo, Dapeng
A1 Liao, Xiaoling
A1 Wang, Chunjuan
A1 Zhao, Xingquan
A1 Pan, Yuesong
A1 Li, Hao
A1 Liu, Liping
A1 Wang, Yilong
A1 Wang, Yongjun
A1 Miao, Zhong-Rong
A1 
YR 2018
UL http://jnis.bmj.com/content/10/8/746.abstract
AB Objective To investigate the safety and efficacy of mechanical thrombectomy plus rescue therapy for intracranial large artery occlusion (ILAO) with underlying intracranial atherosclerosis (ICAS).Methods Patients enrolled in the intervention group of EAST (Endovascular Therapy for Acute ischemic Stroke Trial) were analyzed. For underlying ICAS identified during the stent retrieval procedure, rescue treatment was required for those with (1) a degree of arterial stenosis >70% or (2) any degree of arterial with blood flow impairment or (3) evidence of re-occlusion. Outcomes were compared between the ICAS group and the embolic group. Multivariate logistic regression was performed to determine independent predictors of functional independence at 90 days.Results Among the 140 patients included in the analysis, underlying ICAS was identified in 47 (34%), and 30 patients (21.4%) were considered to be eligible to receive rescue treatment. Of the 30 patients, 27 (90%) actually received rescue therapy. Recanalization rate (95.7% vs 96.8%, P=0.757) and functional independence at 90 days (63.8% vs 51.6%, P=0.169) were comparable between the ICAS group and the embolic group. No significant difference in symptomatic hemorrhage (4.3% vs 4.3%, P=1.000) or death (12.8% vs 12.9%, P=0.982) was found between the two groups. National Institutes of Health Stroke Scale score at presentation (OR=0.865, 95% CI 0.795 to 0.941; P=0.001) and modified Thrombolysis in Cerebral Infarction after the procedure (OR=2.864, 95% CI 1.018 to 8.061; P=0.046) were independently associated with functional independence at 90 days.Conclusions Mechanical thrombectomy is safe in patients with ILAO with underlying ICAS. By employing a standard rescue therapy, favorable outcomes could be achieved in such patients.Clinical trial registration NCT02350283 (Post-results).