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Neurodegeneration
Research paper
Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias

Authors

  • Puja R Mehta Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK Department of Neurology, King's College Hospital, Denmark Hill, London, UK PubMed articlesGoogle scholar articles
  • Ashley R Jones Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Sarah Opie-Martin Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Aleksey Shatunov Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Alfredo Iacoangeli Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Ahmad Al Khleifat Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Bradley N Smith Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Simon Topp Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Karen E Morrison Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK PubMed articlesGoogle scholar articles
  • Pamela J Shaw Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK PubMed articlesGoogle scholar articles
  • Christopher E Shaw Department of Neurology, King's College Hospital, Denmark Hill, London, UK Institute of Psychiatry, Psychology and Neuroscience, UK Dementia Research Institute, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK PubMed articlesGoogle scholar articles
  • Sarah Morgan Department of Molecular Neuroscience, Institute of Neurology, UCL, Queen Square, London, UK PubMed articlesGoogle scholar articles
  • Alan Pittman Department of Molecular Neuroscience, Institute of Neurology, UCL, Queen Square, London, UK PubMed articlesGoogle scholar articles
  • Ammar Al-Chalabi Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK Department of Neurology, King's College Hospital, Denmark Hill, London, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Ammar Al-Chalabi, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London SE5 9RX, UK; ammar.al-chalabi{at}kcl.ac.uk
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Citation

Mehta PR, Jones AR, Opie-Martin S, et al
Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias
Journal of Neurology, Neurosurgery & Psychiatry 2019;90:268-271.

Publication history

  • Received June 23, 2018
  • Revised July 31, 2018
  • Accepted August 18, 2018
  • First published September 30, 2018.
Online issue publication 
July 20, 2023

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: http://creativecommons.org/licenses/by/4.0/