Association between polygenic risk scores (PRS) percentiles and ovarian cancer risk: unadjusted and adjusted by family history of ovarian cancer (FH) in first-degree or in first-degree and second-degree relatives
| PRS percentile category (%) | Controls (n) | Cases (n) | OR (95% CI) | ||
| Unadjusted by FH | Adjusted by first-degree FH | Adjusted by first-degree and second-degree FH | |||
| (a) Overall | |||||
| [0,5) | 72 | 20 | 0.53 (0.30 to 0.89) | 0.53 (0.31 to 0.89) | 0.54 (0.31 to 0.90) |
| [5,10) | 71 | 17 | 0.46 (0.25 to 0.79) | 0.46 (0.25 to 0.79) | 0.46 (0.25 to 0.79) |
| [10,20) | 143 | 47 | 0.63 (0.42 to 0.92) | 0.63 (0.43 to 0.92) | 0.63 (0.43 to 0.92) |
| [20,40) | 285 | 137 | 0.92 (0.69 to 1.22) | 0.92 (0.70 to 1.23) | 0.93 (0.70 to 1.23) |
| [40,60) | 286 | 150 | 1 | 1 | 1 |
| [60,80) | 285 | 159 | 1.06 (0.81 to 1.40) | 1.07 (0.81 to 1.42) | 1.07 (0.81 to 1.41) |
| [80,90) | 143 | 102 | 1.36 (0.99 to 1.88) | 1.37 (0.99 to 1.89) | 1.37 (1.00 to 1.90) |
| [90,95) | 71 | 51 | 1.37 (0.91 to 2.06) | 1.37 (0.91 to 2.06) | 1.37 (0.90 to 2.06) |
| [95,100] | 72 | 67 | 1.77 (1.20 to 2.61) | 1.79 (1.21 to 2.64) | 1.78 (1.21 to 2.62) |
| FH | 1.52 (0.94 to 2.44) | 1.28 (0.88 to 1.87) | |||
| (b) Serous | |||||
| [0,5) | 72 | 12 | 0.51 (0.25 to 0.94) | 0.51 (0.25 to 0.94) | 0.51 (0.25 to 0.95) |
| [5,10) | 71 | 10 | 0.43 (0.20 to 0.83) | 0.43 (0.20 to 0.82) | 0.43 (0.20 to 0.83) |
| [10,20) | 141 | 33 | 0.71 (0.45 to 1.10) | 0.72 (0.46 to 1.11) | 0.72 (0.45 to 1.11) |
| [20,40) | 287 | 78 | 0.83 (0.59 to 1.16) | 0.83 (0.59 to 1.17) | 0.83 (0.59 to 1.17) |
| [40,60) | 286 | 94 | 1 | 1 | 1 |
| [60,80) | 285 | 102 | 1.09 (0.79 to 1.51) | 1.09 (0.79 to 1.51) | 1.09 (0.79 to 1.51) |
| [80,90) | 143 | 68 | 1.45 (1.00 to 2.10) | 1.45 (1.00 to 2.10) | 1.45 (1.00 to 2.10) |
| [90,95) | 71 | 41 | 1.76 (1.12 to 2.75) | 1.77 (1.13 to 2.77) | 1.77 (1.12 to 2.77) |
| [95,100] | 72 | 51 | 2.16 (1.40 to 3.30) | 2.15 (1.40 to 3.30) | 2.14 (1.39 to 3.28) |
| FH | 1.54 (0.88 to 2.63) | 1.36 (0.88 to 2.08) | |||