Histopathology of BRCA1 1706A and 1708E breast tumours
| Histopathological feature | G1706A (Australian pedigree no. 1) | G1706A (Spanish pedigree) | A1708E (Australian pedigree) | A1708E (UK pedigree no. 2) |
|---|---|---|---|---|
| Histopathology shows that only the 1708E associated tumours have a typical BRCA1-like phenotype. | ||||
| Histological subtype of invasive carcinoma | Ductal/no special type | Ductal/lobular | Medullary | Atypical medullary |
| Mitotic count | Score 1 (actual count 1) | Score 1 | Score 3 (actual count 85) | Score 3 (actual count 103) |
| Overall histological grade | Grade 2 | Grade 2 | Grade 3 | Grade 3 |
| % Tumour diameter as continuous pushing margin | Absent | Absent | >75% | >75% |
| Confluent necrosis | Absent | Absent | Present | Absent |
| Tumour cells: discernible cell borders | Present | Present | Absent | Absent |
| ER/PR status | Data not available | ER+, PR− | ER−, PR− | ER−, PR− |
| Conclusion | Not BRCA1-like | Not BRCA1-like | BRCA1-like | BRCA1-like |