Clinical Pharmacology

Omission of dexamethasone in paclitaxel premedication regimens: protocol of the multicentre, randomised, non-inferiority DEXASTOP trial
Michiel Zietse, Luuk C Aalders, Leontine E A M M Spierings, Nikki De Rouw, Wouter Dercksen, Virgil A S H Dalm, Esther Oomen-de Hoop, Frederick W Thielen, Birgit C P Koch, Ron H J Mathijssen, Leni van Doorn, Roelof W F van Leeuwen

BMJ Open Apr 2025, 15 (4) e102770; DOI: 10.1136/bmjopen-2025-102770
Cost-effectiveness analysis of aducanumab versus placebo for patients with mild cognitive impairment and mild Alzheimer’s disease
Xiaomo Xiong, Gang Lv, Jacob Jordan King, Minghui Li, Jing Yuan, Z Kevin Lu

BMJ Open Apr 2025, 15 (4) e090403; DOI: 10.1136/bmjopen-2024-090403
Views of key stakeholders on deprescribing preventive medication in people living with dementia: a qualitative systematic review protocol
Clare Bates, Nikolaos Efstathiou, Claire Sutton, Nesrein Hamed, Ian Maidment

BMJ Open Mar 2025, 15 (3) e085812; DOI: 10.1136/bmjopen-2024-085812
HiSNAP trial—a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 600 mg/kg) in patients with paracetamol overdose in the UK: study protocol
Christopher Humphries, Ellise Clarke, Michael Eddleston, Marianne Gillings, Sian Irvine, Liza Keating, Anna Miell, Lynsey Milne, Laura Muir, Rachel O’Brien, Katherine Oatey, Rajendra Raman, Ruben Thanacoody, Sharon Tuck, Christopher J Weir, David M Wood, James W Dear

BMJ Open Mar 2025, 15 (3) e097432; DOI: 10.1136/bmjopen-2024-097432
Tebipenem pivoxil as an alternative to ceftriaxone for clinically non-responding children with shigellosis: a randomised non-inferiority trial protocol
Sharika Nuzhat, Md Ridwan Islam, Subhasish Das, Syed Jayedul Bashar, Patricia B Pavlinac, Samuel L Arnold, Amy Newlands, Rachel Gibson, Elena Fernandez Alvaro, Juliet Addo, Farhana Khanam, Dilruba Ahmed, Md Jobayer Chisti, Firdausi Qadri, Tahmeed Ahmed

BMJ Open Feb 2025, 15 (2) e088449; DOI: 10.1136/bmjopen-2024-088449
Co-creating tools for embedding meaningful patient and public involvement and engagement in real-world data and evidence research in the pharmaceutical industry setting: a multistakeholder participatory co-design study
Sally A Dews, Lynne Corner, Rebecca Butfield, Mary Araghi, Hannah Monelle, Polly Westergaard, Susan Moloney, Viola Wontor, Alexia Campbell Burton

BMJ Open Feb 2025, 15 (2) e088914; DOI: 10.1136/bmjopen-2024-088914
Temporal trends in guideline-recommended medical therapy after an acute heart failure decompensation event: an observational analysis from Generator Heart Failure DataMart
Renzo Laborante, Agni Delvinioti, Andrada Mihaela Tudor, Jacopo Lenkowicz, Chiara Iacomini, Antonio Iaconelli, Donato Antonio Paglianiti, Mattia Galli, Daniele Rodolico, Stefano Patarnello, Attilio Restivo, Giuseppe Ciliberti, Gaetano Rizzo, Emiliano Bianchini, Matteo Busti, Luca Sensini, Vincenzo Valentini, Giovanni Scambia, Antonio Gasbarrini, Filippo Crea, Alfredo Cesario, Gianluigi Savarese, Giuseppe Patti, Domenico D'Amario

BMJ Open Feb 2025, 15 (2) e088998; DOI: 10.1136/bmjopen-2024-088998
Practices and knowledge of community pharmacists towards the use of proton pump inhibitors: a cross-sectional study in Jordan
Lobna Gharaibeh, Mariam Ahmad Alameri, Mai I AL-Hawamdeh, Enas Daoud, Randa Atwan, Zainab Lafi, Zainab Zaki Zakaraya

BMJ Open Feb 2025, 15 (2) e085589; DOI: 10.1136/bmjopen-2024-085589
Phase I trial on the safety of olprinone for low central venous pressure management aimed at haemorrhage control during open and laparoscopic hepatectomy: a study protocol
Yuya Miura, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Yoshiyasu Kato, Takuya Oyakawa, Eiji Ando, Sunao Tamai, Katsuhiko Uesaka

BMJ Open Feb 2025, 15 (2) e088307; DOI: 10.1136/bmjopen-2024-088307
What is the current scope of research assessing patients’ and clinicians’ perspectives on clozapine treatment? A comprehensive scoping review
Michelle Iris Jakobsen, Julie Perrine Schaug, Ole Jakob Storebø, Stephen F Austin, Jimmi Nielsen, Erik Simonsen

BMJ Open Jan 2025, 15 (1) e085956; DOI: 10.1136/bmjopen-2024-085956

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