Mean increase from the prevalence round to the incidence round in the Consequences Of Screening in Lung Cancer (COS-LC) questionnaire outcomes in the participants in the control group and the participants with negative screening results in the screening group of the DLCST study
| Range of values | Control group, n=2052 | Screen group, n=1873 | p Value¶ | |||
| Mean increase (SE) | p Value† ‡ | Mean increase (SE) | p Value‡ § | |||
| COS scales | ||||||
| Anxiety | 0–18 | 0.1275 (0.0689) | 0.0644 | 0.0299 (0.0657) | 0.6493 | 0.3056 |
| Behaviour | 0–21 | 1.1962 (0.0770) | <0.0001* | 1.0535 (0.0690) | <0.0001* | 0.1681 |
| Dejection | 0–18 | 0.5371 (0.0750) | <0.0001* | 0.4076 (0.0686) | <0.0001* | 0.2031 |
| Sleep | 0–12 | 1.1025 (0.0651) | <0.0001* | 1.0271 (0.0585) | <0.0001* | 0.3887 |
| Single items | ||||||
| Busy to take mind off things | 0–3 | 0.0760 (0.0189) | <0.0001* | 0.0539 (0.0173) | 0.0019* | 0.3903 |
| Less interest in sex | 0–3 | 0.1811 (0.0348) | <0.0001* | 0.2253 (0.0318) | <0.0001* | 0.3490 |
| Self-rated health | 0–4 | 0.0196 (0.0185) | 0.2898 | −0.0270 (0.0165) | 0.1018 | 0.0605 |
↵† p Value from a t test pertaining to the increase in the control group.
↵‡ Controlling for multiple testing by setting the false discovery rate to maximum 5% with the method of Benjamini–Hochberg, the significance level was taken to be p<0.0238 (indicated by*).
↵§ p Value from a t test pertaining to the increase in the screen group.
↵¶ p Value from a t test pertaining to the difference in increase between the control and the screen groups.
COS, Consequences Of Screening; DLCST, Danish Lung Cancer Screening Trial.