Characteristics of the cohort
| All | Males | Females | |
| N | 141 272 | 73 903 (52.3) | 67 369 (47.7) |
| Age (years) | 63.2±13.4 | 62.8±12.4 | 63.6±14.5 |
| Age group count (%) | |||
| 18–44 | 12 896 (9.1) | 5619 (7.6) | 7277 (10.8) |
| 45–54 | 22 717 (16.1) | 12 934 (17.5) | 9783 (14.5) |
| 55–64 | 36 790 (26.0) | 21 127 (28.6) | 15 663 (23.3) |
| 65–74 | 39 178 (27.7) | 21 042 (28.5) | 18 136 (26.9) |
| 75–84 | 23 801 (16.9) | 11 019 (14.9) | 12 782 (19.0) |
| ≥85 | 5890 (4.2) | 2162 (2.9) | 3728 (5.5) |
| Smoking status count (%) | |||
| Current | 21 088 (14.9) | 11 352 (15.4) | 9736 (14.5) |
| Ex | 46 301 (32.8) | 27 979 (37.9) | 18 322 (27.2) |
| Never | 27 834 (19.7) | 12 046 (16.3) | 15 788 (23.4) |
| Missing | 46 049 (32.6) | 22 526 (30.5) | 23 523 (34.9) |
| BMI categories (kg/m2) count (%) | |||
| <18.5 | 628 (0.4) | 153 (0.2) | 475 (0.7) |
| 18.5–25 | 11 553 (8.2) | 5504 (7.5) | 6049 (9.0) |
| 25–30 | 27 523 (19.5) | 16 686 (22.6) | 10 837 (16.1) |
| ≥30 | 42 456 (30.1) | 21 189 (28.7) | 21 267 (31.6) |
| Missing | 59 112 (41.8) | 30 371 (41.1) | 28 741 (42.7) |
| Cholesterol (%) count (%) | |||
| <3 | 1538 (1.1) | 1203 (1.6) | 336 (0.5) |
| 3–4 | 12 668 (9.0) | 8814 (11.9) | 3859 (5.7) |
| 4–5 | 29 204 (20.7) | 17 170 (23.2) | 12 041 (17.9) |
| 5–6 | 28 554 (20.2) | 14 889 (20.1) | 13 670 (20.3) |
| ≥6 | 22 818 (16.2) | 9844 (13.3) | 12 979 (19.3) |
| Missing | 46 490 (32.9) | 22 002 (29.8) | 24 513 (36.4) |
| Depression | 26 064 (18.5) | 9724 (13.2) | 16 340 (24.3) |
| CCI score count (%) | |||
| None | 120 158 (85.1) | 63 571 (86.0) | 56 587 (84.0) |
| 1–2 | 20 912 (14.8) | 10 215 (13.8) | 10 697 (15.9) |
| 3–4 | 142 (0.1) | 85 (0.1) | 57 (0.1) |
| >4 | 60 (0.04) | 32 (0.04) | 28 (0.04) |
| Patient-level deprivation index (2010 IMD score) count (%) | |||
| Quintile 1(most affluent) | 12 854 (9.1) | 7034 (9.5) | 5820 (8.6) |
| Quintile 2 | 13 617 (9.6) | 7368 (10.0) | 6249 (9.3) |
| Quintile 3 | 12 882 (9.1) | 6692 (9.1) | 6190 (9.2) |
| Quintile 4 | 12 816 (9.1) | 6514 (8.8) | 6302 (9.4) |
| Quintile 5 (least affluent) | 9866 (7.0) | 4780 (6.5) | 5086 (7.6) |
| Missing | 79 237 (56.1) | 41 515 (56.2) | 37 722 (56.0) |
BMI, body mass index; CCI, Charlson Comorbidity Index; IMD, Index of Multiple Deprivation.