Summary of articles with models predicting complications in severe malaria
| N | Study | Year | Period of participant recruitment | Country | Type of study | Sample size | Statistics used | Name of model | Method internal of validation | Age profiles | Sex profiles | Outcome predicted | Variables used | Diagnostic properties | External validation | Use in clinical settings |
| Complications of malaria severe anaemia | ||||||||||||||||
| 1 | Weber et al 15 | 1997 | July to December 1994 | Gambia | Cohort | 368 | Logistic regression | None | None | Median age: 28 months (IQR: 14–48 months) | Females—49% | Paediatric development of severe anaemia in malaria (packed cell volume <15%) | Pallor of conjunctiva and pallor of palms | Sensitivity of 80% and a specificity of 85%. | None | NE |
| Development of sepsis | ||||||||||||||||
| 2 | Njim et al 8 | 2018 | June 2003 to May 2005 | Bangladesh, India, Indonesia and Myanmart | Randomised control trial | 1187 | Logistic regression | None | Bootsrapping | 17–87 years | Female—24.3% | Development of clinical sepsis in adults with severe falciparum malaria | Sex, blood urea nitrogen levels, plasma anion gap, respiratory distress, shock on admission, parasitaemia, coma and jaundice | AUC: 0.789. Sensitivity—70.0%; specificity—69.4% | None | NE |
AUC, area under the curve; NE, no evidence.