Table 2

Schedule of enrolment, interventions and assessments

Timepoint	Study period
	Screening and eligibility	Allocation	Post allocation									Close-out
	−T1	0	T1	T2	T3	D8–15	T4	T5	T6	T7	T8	T9
D=day, W=week	−T1	D0	D1	D2–6	D7	D8–15	D14	D21	W6	W12	W24	W48
Enrolment
Eligibility screen	✓	✓
Neurological and musculoskeletal examination	✓	✓
Safety blood tests	✓	✓	✓		✓			✓
MRI (or CT if MRI contraindicated or CT clearly demonstrates imaging pathology)	✓
Oswestry Disability Index	✓	✓
Informed consent	✓
Allocation		✓
Interventions
Procedural injection in radiology suite		X
Oral medications		X	X	XXXX	X	XXXX XXXX
Assessments
Outcome variables
Oswestry disability index	✓	✓	✓	✓	✓		✓	✓	✓	✓	✓	✓
Numerical pain rating scales	✓	✓	✓	✓	✓		✓	✓	✓	✓	✓	✓
Pain DETECT Questionnaire	✓	✓	✓		✓		✓	✓	✓	✓	✓	✓
SF-36	✓	✓			✓		✓	✓	✓	✓	✓	✓
EQ-5D-5L	✓	✓	✓		✓		✓	✓	✓	✓	✓	✓
Work/health utilisation/costs	✓	✓	✓		✓		✓	✓	✓	✓	✓	✓
Medication history	✓	✓	✓	✓	✓		✓	✓	✓	✓	✓	✓
Neurological and musculoskeletal examination			✓		✓			✓	✓	✓	✓	✓
Safety blood tests			✓		✓
Other data variables
Rescue procedure history			✓		✓			✓	✓	✓	✓	✓
Participation randomisation perception			✓		✓			✓	✓	✓	✓	✓
Adverse events and serious adverse event assessment		✓	✓	✓	✓			✓	✓	✓	✓	✓