Surgery

del Nido versus St. Thomas’ blood cardioplegia in the young (DESTINY) trial: protocol for a multicentre randomised controlled trial in children undergoing cardiac surgery
Nigel E Drury, Kelly Handley, Hugh Jarrett, Tina Griffin, Yongzhong Sun, Indie Bilkhoo, Alex Robertson, Carly Tooke, Barnaby R Scholefield, Warwick B Dunn, Martin Kostolny, Serban Stoica, Carin van Doorn, John V Pappachan, Timothy J Jones, Massimo Caputo

BMJ Open Apr 2025, 15 (4) e102029; DOI: 10.1136/bmjopen-2025-102029
SMALL: open surgery versus minimally invasive vacuum-assisted excision for small screen-detected breast cancer—protocol for a phase III randomised multicentre trial
Kenneth Elder, Charlotte Coles, David Dodwell, Beatrix Elsberger, Jessica Foster, Claire Gaunt, Julia R Henderson, Iain Lyburn, Claire Mabena, Jenna Morgan, Zohal Nabi, Sangeetha Paramasivan, Sarah Pinder, Sarah Pirrie, Shelley Potter, Tracy Roberts, Nisha Sharma, Elizabeth Southgate, Hilary Stobart, Amruta Talwalkar, Sian Taylor-Phillips, William Teh, Elliot Turner, Matthew G Wallis, Dan Rea, Stuart McIntosh

BMJ Open Apr 2025, 15 (4) e099702; DOI: 10.1136/bmjopen-2025-099702
Perioperative metformin use in patients undergoing total joint replacement surgery: protocol for a randomised, placebo-controlled pilot study
Aidan Morrell, Steven Shelofsky, Hannah Hoffman, Cole McCallister, Thomas W Huff, Kathryn L Schabel, Avital Y O’Glasser, Ryland P Kagan

BMJ Open Apr 2025, 15 (4) e091446; DOI: 10.1136/bmjopen-2024-091446
Incidence, risk factors and airway management of postoperative haematoma following anterior cervical spine surgery: a retrospective nested case-control study
Yang Tian, Jiao Li, Guangjin Zhou, Mingya Wang, Yinyin Qu, Min Li, Jun Wang, Mao Xu, Shenglin Wang, Xiangyang Guo, Yongzheng Han

BMJ Open Apr 2025, 15 (4) e090547; DOI: 10.1136/bmjopen-2024-090547
Comparing Analgesic Regimen Effectiveness and Safety after Surgery (CARES): protocol for a pragmatic, international multicentre randomised trial
Mark C Bicket, Karim Shiraz Ladha, Simon Haroutounian, Kellie McFarlin, Mary Neff, Rachel L McDuffie, Jennifer F Waljee, Duminda Nalaka Wijeysundera, Chad Brummet, Yi Li

BMJ Open Apr 2025, 15 (4) e099925; DOI: 10.1136/bmjopen-2025-099925
Omission of axillary lymph node dissection in patients with breast cancer with axillary pathological complete response confirmed by stained region lymph node biopsy after neoadjuvant systemic therapy (SrLNB study): study protocol for a single-arm, single-centre, phase-II trial
Lingjun Ma, Rui Chen, Mingyu Wang, Xuan Li, Ran Zheng, Lexin Wang, Jingjing Ding, Hao Yao, Yichun Gong, Yuanyuan Wang, Xingye Sheng, Jue Wang, Xiaoming Zha

BMJ Open Mar 2025, 15 (3) e092563; DOI: 10.1136/bmjopen-2024-092563
Prevalence of socioeconomic deprivation and risk factors in patients on the elective surgery waiting list in the North East and North Cumbria region of England: a cross-sectional study
Claire D Madigan, James Prentis, Edward Kunonga, Chris Snowden, Mackenzie Fong, Sophia Margarita Brady, Bob Gaffney, Eileen F S Kaner

BMJ Open Mar 2025, 15 (3) e097440; DOI: 10.1136/bmjopen-2024-097440
Cost-effectiveness of total shoulder arthroplasty compared with hemiarthroplasty: a study using data from the National Joint Registry
Andrew Davies, Bernarda Zamora-Talaya, Sanjeeve Sabharwal, Alexander D Liddle, Martinique Vella-Baldacchino, Amar Rangan, Peter Reilly

BMJ Open Mar 2025, 15 (3) e086150; DOI: 10.1136/bmjopen-2024-086150
Approaches for thoracoabdominal oesophagectomy for oesophageal cancer: a network meta-analysis – study protocol
Artur Rebelo, Juliane Friedrichs, Maurizio Grilli, Johannes Vey, Johannes Klose, Marie Merling, Joerg Kleeff, Ulrich Ronellenfitsch

BMJ Open Mar 2025, 15 (3) e093561; DOI: 10.1136/bmjopen-2024-093561
Obsidian ASG autologous platelet-rich fibrin matrix for the prevention of postoperative pancreatic fistula following pancreatic resection: study protocol for a feasibility trial at the Medical University of Vienna
Charlotte Gustorff, Christopher Dawoud, Carl-Stephan Leonhardt, Stefan Riss, Klaus Sahora, Martin Schindl, Oliver Strobel, Ulla Klaiber

BMJ Open Mar 2025, 15 (3) e088867; DOI: 10.1136/bmjopen-2024-088867

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