RT Journal Article
SR Electronic
T1 Increased seizure frequency in an epilepsy patient receiving medium cut-off dialysis
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e250911
DO 10.1136/bcr-2022-250911
VO 15
IS 11
A1 Lean, Maria
A1 May, Stephen
A1 McLucas, Michael
A1 Green, Malcolm
YR 2022
UL http://casereports.bmj.com/content/15/11/e250911.abstract
AB This paper presents the case of a male dialysis patient, with generalised epilepsy, who experienced complications after starting medium cut-off (MCO) dialysis. While receiving haemodiafiltration, the patient’s epilepsy had been relatively well controlled using two antiseizure medications (brivaracetam and sodium valproate). However, the patient’s seizure frequency increased when he was changed to MCO dialysis. MCO is a new dialysis method that has been developed to allow for better clearance of uraemic toxins through its larger pore size. We hypothesise that using the highly permeable MCO membrane changed the seizure threshold by an unknown mechanism. This is the first reported case to observe increased seizure frequency in a patient receiving MCO dialysis. The case highlights the need for caution when prescribing dialysis methods to patients with epilepsy.