RT Journal Article
SR Electronic
T1 Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e243395
DO 10.1136/bcr-2021-243395
VO 14
IS 9
A1 Shiraishi, Wataru
A1 Tsujimoto, Yoshitaka
A1 Shiraishi, Tomoko
YR 2021
UL http://casereports.bmj.com/content/14/9/e243395.abstract
AB The most common neurological manifestation of eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is mononeuritis multiplex caused by small-vessel vasculitis. In contrast, central nervous system involvement is rare. Among EGPA-associated central nervous system disorders, there are only a few reported cases of hypertrophic pachymeningitis (HP). Here, we report a patient with EGPA with headache and ophthalmoplegia who presented with HP and had a dural biopsy. The biopsy specimen showed lymphocytic inflammatory cell infiltration without EGPA-specific findings, that is, eosinophilic infiltration, granuloma or angiitis. To the best of our knowledge, there are no previous reports of EGPA-associated HP pathology. Here, we report the first case presentation of a patient with EGPA-associated HP with pathological findings.