PT  - JOURNAL ARTICLE
AU  - Shiraishi, Wataru
AU  - Tsujimoto, Yoshitaka
AU  - Shiraishi, Tomoko
TI  - Pathological findings of hypertrophic pachymeningitis associated with eosinophilic granulomatosis with polyangiitis
AID  - 10.1136/bcr-2021-243395
DP  - 2021 Sep 01
TA  - BMJ Case Reports
PG  - e243395
VI  - 14
IP  - 9
4099  - http://casereports.bmj.com/content/14/9/e243395.short
4100  - http://casereports.bmj.com/content/14/9/e243395.full
SO  - BMJ Case Reports2021 Sep 01; 14
AB  - The most common neurological manifestation of eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is mononeuritis multiplex caused by small-vessel vasculitis. In contrast, central nervous system involvement is rare. Among EGPA-associated central nervous system disorders, there are only a few reported cases of hypertrophic pachymeningitis (HP). Here, we report a patient with EGPA with headache and ophthalmoplegia who presented with HP and had a dural biopsy. The biopsy specimen showed lymphocytic inflammatory cell infiltration without EGPA-specific findings, that is, eosinophilic infiltration, granuloma or angiitis. To the best of our knowledge, there are no previous reports of EGPA-associated HP pathology. Here, we report the first case presentation of a patient with EGPA-associated HP with pathological findings.