You are here

Article Text

Article menu
Download PDFPDF
Ophthalmology
Iris metastasis: clues to the primary through immunohistochemistry
  1. Mohammed Almanassra1,
  2. Soumya Sucharita2,
  3. Srikanta Kumar Padhy3 and
  4. Devjyoti Tripathy1
  1. 1Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India
  2. 2Kanupriya Dalmia Ophthalmic Pathology Laboratory, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India
  3. 3Vitreoretinal Service, Anant Bajaj Retina Institute, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India
  1. Correspondence to Dr Devjyoti Tripathy; devjyoti{at}lvpei.org

Abstract

A woman in her late 40s was referred to our tertiary care ocular oncology specialty clinic with the complaint of an elevated mass on the iris of the left eye of about 6 weeks’ duration. The vision in the affected eye was normal and there were no associated ocular or systemic complaints. The left eye had a solitary amelanotic nodule with intrinsic vessels on the temporal iris. An excision biopsy with histopathology revealed features of metastatic adenocarcinoma. Immunohistochemistry workup pointed towards a primary in the lungs. A high-resolution chest CT scan showed an upper lobe mass in the right lung. A whole-body positron emission tomography–CT (PET–CT) scan showed this lesion to be metabolically active. Additionally, it showed active mediastinal and supraclavicular lymph nodes, and active lesions in the brain parenchyma. The patient received chemo- and radiation therapy with palliative intent at a general oncology facility.

  • Iris
  • Pathology
  • Oncology

https://doi.org/10.1136/bcr-2025-264917

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • X @devtripathyNU

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: DT, MA, SS, SKP. The following authors gave final approval of the manuscript: DT, MA, SS, SKP. Guarantor: DT.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.