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  • Malignant peripheral nerve sheath tumour (MPNST) of the cervix: differential diagnosis and a favourable oncological outcome with multimodality treatment

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Oncology
Malignant peripheral nerve sheath tumour (MPNST) of the cervix: differential diagnosis and a favourable oncological outcome with multimodality treatment
  1. Divya Sehra1 and
  2. Sarita Kumari2
  1. 1Obstetrics and Gynaecology, All India Institute of Medical Sciences, Gurgaon, Haryana, India
  2. 2Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  1. Correspondence to Dr Divya Sehra; divi.sehra2011{at}gmail.com

Abstract

Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive sarcomas that occur rarely in the cervix. Considering the varied clinical features and the absence of a pathognomonic immunohistochemical marker, it is always challenging to diagnose these tumours. Treatment has not been standardised as yet, but a combination of surgery, radiotherapy and chemotherapy is used to treat MPNSTs of the cervix. Here, we report a case of a woman in her 40s with a 10×7 cm polypoidal lesion in the cervix, diagnosed as an MPNST. She was treated with surgery, ifosfamide-based chemotherapy and external beam radiotherapy before developing pulmonary metastases. She was treated with stereotactic body radiotherapy for the pulmonary metastases, and the patient has been on follow-up since then. We are also summarising the clinicopathological findings, surgical treatment and follow-up of all reported cases of cervical MPNSTs to date.

  • Cancer - see Oncology
  • Cervical cancer
  • Cervix Uteri
  • Surgical oncology

https://doi.org/10.1136/bcr-2024-260709

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    Footnotes

    • Contributors The following authors were responsible for the drafting of the text, the sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and the critical revision for important intellectual content: DS and SK. DS is the guarantor. The following authors gave the final approval of the manuscript: DS and SK.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.