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Obstetrics and gynaecology
Aggressive precursor B cell ALL of cervix with obstructive uropathy
  1. Anupama Bahadur1,
  2. Rajlaxmi Mundhra1,
  3. Poonam Gill1 and
  4. Ashok Singh2
  1. 1Obstetrics and Gynaecology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India
  2. 2Pathology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India
  1. Correspondence to Dr Rajlaxmi Mundhra; rmundhra54{at}yahoo.com

Abstract

Involvement of the cervix with acute lymphoblastic leukaemia (ALL) is extremely rare. In this case report, we discuss an unmarried woman in her early 20s, who presented in the emergency with lower abdominal pain and irregular vaginal bleeding for 1 month. Clinical examination and imaging revealed a large cervical mass probably neoplastic with obstructive uropathy. On evaluation, she was diagnosed incidentally with CALLA-positive precursor B cell ALL in peripheral blood flow cytometry. Involvement of B cell ALL in cervical mass was confirmed by histopathological examination of cervical biopsy and immunohistochemistry markers. Her history was not suggestive of signs and symptoms pertaining to leukaemia. Literature is sparse with only a few cases reporting cervical leukaemic infiltration. The present case report is a rarest case where the primary/initial presentation of precursor B cell ALL was seen with cervical involvement and obstructive uropathy mimicking characteristics of advanced cervical malignancy.

  • Obstetrics and gynaecology
  • Oncology
  • Haematology (incl blood transfusion)

https://doi.org/10.1136/bcr-2023-258313

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    Footnotes

    • Contributors AB, RM, PG and AS were responsible for the drafting of the text, sourcing and editing of clinical images, investigation results and critical revision for important intellectual content. AB and RM gave final approval of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.